Jobs

Postdoctoral Position

Employer

Case Western Reserve University

Location

Cleveland, Ohio

Principal Investigator

Jiri Safar

Contact

Please submit CV, names and contact information for three references, and a description of your research experience to Dr. Safar, Jiri.Safar@case.edu.

Description

The laboratory of Dr. Jiri Safar in the Department of Pathology at the Case Western Reserve University School of Medicine has a postdoctoral position open to study biological, biophysical, and translational aspects of Alzheimer’s disease and neurodegenerative diseases caused by misfolded proteins. The position is available under the NIH five-year grant award in collaboration with the Alzheimer’s Disease Center at the New York University Medical School.

The Safar laboratory utilizes cutting edge biophysical and genetic tools including transgenic mice to study the role of misfolded proteins in pathogenesis of neurodegenerative diseases. A recent paper shows that the rate of progression in Alzheimer’s disease is linked to the distinct structural organization of Aβ. Ongoing projects focus on defining the mechanisms of this effect and coupling between different prion-like strains of Aβ, tau protein, and the disease phenotype.

Requirements

These projects would be ideally suited to a postdoctoral candidate with experience in experimental neuropathology of murine Alzheimer’s models, immunohistochemistry, fluorescence microscopy, and techniques of protein biochemistry.