Jobs

Postdoctoral Fellowship in Translational Research in Neurodegeneration

Employer

Emory University

Location

Atlanta, Georgia

Principal Investigator

Thomas Kukar

Contact

tkukar@emory.edu

Description

Two postdoctoral fellowship positions are available in the Kukar lab to study the mechanisms of neurodegeneration and neuroinflammation in AD, FTD, and ALS with the ultimate goal of developing new treatments.

There are two major projects currently: 1) investigating the pathogenesis of RNA-binding proteins (i.e. FUS/TDP-43) in neurodegeneration and 2) understanding how decreased levels of the progranulin (PGRN) protein cause or increase the risk of multiple neurodegenerative diseases (frontotemporal dementia, Alzheimer's disease, Parkinson’s disease, and neuronal ceroid lipofuscinosis). Both projects will utilize a multidisciplinary approach ranging from molecular biology, biochemistry, cell culture, mouse models, IHC/IF, human iPSC models, drug screening, to proteomics.

The lab is part of the highly collaborative Emory Center for Neurodegeneration and the postdocs will have access to state-of-the art equipment and cores to advance their research (http://www.cores.emory.edu/eipc/index.html).

There is also an opportunity to apply for an NINDS T32 Training Grant in Translational Research in Neurology to support the fellowship. The training will have two principal components: first, fellows will be immersed in an intensive, hands-on laboratory training program; second, they will learn clinical aspects of neurologic disorders, including current concepts of pathogenesis and pathophysiology, current therapy and potential “targets” for experimental therapeutic intervention (http://www.cnd.emory.edu/training/index.html).

Interested candidates should send a CV, a cover letter describing research experience and interests, and contacts for three references.

Requirements

Applicants should have a Ph.D. in neuroscience, pharmacology, cell biology, or related field. They must have excellent verbal and written communication skills and a history of scientific publications. Experience in molecular and cellular neurobiology and mouse models is strongly desired.

Experience with neurodegenerative research, biochemistry, primary neuronal cultures, CRISPR/Cas9 techniques, proteomics, or human iPSC modeling is a plus, but not required. Finally, applicants should be able to work independently and in a fun team environment as necessary.