Jobs

Postdoctoral Fellowship in Alzheimer's Disease Biomarkers

Employer

The National Institute on Aging

Location

Baltimore, Maryland, U.S.A.

Principal Investigator

Madhav Thambisetty

Contact

To apply, please send curriculum vitae, a brief description of research interests, and three letters of reference to: Madhav Thambisetty, M.D., Ph.D., Chief, Unit of Clinical and Translational Neuroscience, Laboratory of Behavioral Neuroscience, at thambisettym@mail.nih.gov, or at Biomedical Research Center, 251 Bayview Blvd., Suite 100, Room 4B317, Baltimore, Maryland 21224-6825.

Description

The National Institute on Aging (NIA), a major research component of the National Institutes of Health (NIH) and the Department of Health and Human Services (HHS), is recruiting a postdoctoral fellow with interests in biomarker discovery for Alzheimer’s disease (AD) in the Unit of Clinical and Translational Neuroscience, within the Laboratory of Behavioral Neuroscience.

This research represents an exciting new initiative within the NIA intramural research program (IRP) to discover biologically relevant biomarkers that accurately reflect AD neuropathology and identify potential targets for effective disease modification/intervention.

In these studies, we use a variety of "Omics" approaches in both blood and brain tissue, including proteomics, metabolomics, and protein array techniques.  E.g., Association of plasma clusterin concentration with severity, pathology and progression in Alzheimer’s disease. ARCHIVES OF GENERAL PSYCHIATRY 67(7): 739-748 (2010); Proteome-based plasma markers of brain amyloid beta deposition in non-demented older individuals. JOURNAL OF ALZHEIMER’S DISEASE 22(4):1099-109 (2010); Plasma biomarkers of brain atrophy in Alzheimer’s disease. PLoS ONE 6(12):e28527 (2011); Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment. NEUROIMAGE 59(1):212-7 (2012).

Requirements

HHS and NIH are Equal Opportunity Employers.  The NIH is dedicated to building a diverse community in its training and employment programs.

The successful candidate will have research interests in and expertise with analysis of large "Omics" datasets. Experience with longitudinal data analysis will be an advantage. Candidates familiar with bioinformatic approaches to data mining and analysis of large datasets such as electronic health records will also be considered. Strong writing skills are desirable. Fellowship duration is typically three-four years.  The successful individual must have a Ph.D., M.D., or equivalent degree with less than five years of postdoctoral research experience. The position is located in Baltimore, a city with a stimulating scientific and cultural environment, with proximity to the Johns Hopkins medical campus.  Salary is commensurate with experience and accomplishments.