Jobs

Postdoctoral Fellows – Molecular Mechanisms of Parkinson’s Disease

Employer

Mayo Clinic

Location

Jacksonville, Florida

Principal Investigator

Wolfdieter Springer

Contact

Interested candidates should send their curriculum vitae, a statement of research experience and interests, and contact information for two to three references to Wolfdieter Springer, Ph.D., Associate Professor, Department of Neuroscience, Mayo Clinic, Springer.Wolfdieter@mayo.edu.

Description

Postdoctoral fellowships are available immediately in the laboratory of Dr. Wolfdieter Springer to conduct research funded by the NIH, DoD, and MJFF on mitochondrial quality control in Parkinson’s disease. The laboratory is studying PINK1/Parkin/phospho-ubiquitin signaling pathways using clinical and pathological specimens and a combination of genomic, transcriptomic, proteomic, and metabolomic analyses. Its researchers implement molecular, structural, cellular, and biochemical studies and develop novel genome-engineered cell models, while employing state-of-the-art microcopy such as high content and super-resolution imaging and performing structure/function-based drug design and high-throughput screening of chemical and genomic libraries.

Specific areas of interest include structural and functional analyses of the ubiquitin kinase PINK1 and the ubiquitin ligase Parkin as well as the identification and dissection of key regulators of mitochondrial quality control. The lab’s aim is to develop novel biomarkers and small molecule therapeutics for age-related neurodegenerative diseases where mitochondrial and/or autophagic/lysosomal dysfunction emerge as a common leitmotif.

Requirements

Candidates with a recent Ph.D. or M.D./Ph.D. and a strong research background in biochemistry, cell biology, and structural biology are encouraged to apply. Candidates must have a record of peer-reviewed publications. Experience in molecular biology, neuroscience, systems biology, integration of different omics datasets, and/or bioinformatics is desirable. The Mayo Clinic offers a competitive stipend and a generous fringe benefit package.