Posted 08 Aug 2017
Research Foundation for Mental Hygiene at the Center for Dementia Research, Nathan S. Kline Institute
Orangeburg, New York
Postdoctoral positions are available in the laboratory of Efrat Levy for outstanding, highly motivated postdoctoral research fellows to play a major role in state-of-the-science integrative studies of Alzheimer’s disease and related neurodegenerative conditions.
The projects for these positions focus on:
(a) defining the mechanisms regulating exosome generation, secretion, and their content, to test the hypothesis that pathogenic alterations of the endosomal/lysosomal pathway in Alzheimer’s disease disrupts brain exosome release. Furthermore, this study aims to demonstrate that restoring normal exosome production may be an innovative therapeutic approach for reducing endosomal/lysosomal pathway pathology in Alzheimer’s disease.
(b) Studying our hypothesis that the interaction between Italian A (AIt), which contains an amino acid substitution at residue 2 of A, and wild-type Aβ hinders Aβ oligomerization, amyloidogenesis, and neurotoxicity, and investigating the mechanism(s) by which AIt is protective. The proposed research will develop exosomes as vehicles to deliver protective AIt within the brain, a novel therapeutic approach for Alzheimer’s disease.
These studies routinely employ multidisciplinary approaches, including behavioral tests of mouse models, mouse and human postmortem immunohistochemistry, biochemical analyses including western blot and ELISA, and in vitro models of Alzheimer’s disease.
Candidates should be highly motivated and enthusiastic researchers with a recent Ph.D. or the equivalent, and must have a strong research background as evidenced by peer-reviewed publications in international journals.
To apply please send full C.V., a brief statement of current research and long-term goal, and names and contact information of three references to Giselle Ferrari (GFerrari@NKI.RFMH.ORG).