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Miami: When Does Amyloid Deposition Start in Familial Alzheimer’s?
1
March 2012.
Three speakers presented data on brain amyloid deposition in presymptomatic carriers of deterministic AD mutations starting as early as their young twenties...
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Anti-Amyloid Treatment in Asymptomatic AD Trial
27
December 2011.
Q&A With Reisa Sperling, Brigham and Women’s Hospital, who leads the A4 trial with Paul Aisen, University of California, San Diego. Questions by Gabrielle Strobel...
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Reeling In Biomarker Data in Young Carriers, API Rocks Staging Boat
23
December 2011.
Scientists driving the Alzheimer's Prevention Initiative have been reporting at scientific conferences the first emerging biomarker findings from their human volunteers...
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DIAN Forms Pharma Consortium, Submits Treatment Trial Grant
22
December 2011.
In their quest to offer treatment trials to families with autosomal-dominant AD, the scientists driving the DIAN have cleared the next hurdles...
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News Flash: Colombian Families Come to Phoenix for Amyloid PET
5
October 2011.
All those who follow the Alzheimer's Prevention Initiative may want to check out a recent New York Times article...
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Formal Guidelines Issued for Alzheimer’s Genetic Testing
15
July 2011.
Communicating genetic information about Alzheimer’s disease to patients and families can be a daunting challenge...
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News Flash: CNN Documentary on Alzheimer’s Disease
28
January 2011.
For all readers who are looking forward to watch Filling the Blank, here is new information Alzforum learned today...
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Mark Your Calendars: Powerful CNN Documentary on Alzheimer’s
21
January 2011.
Invite your friends over, gather loved ones, serve some good munchies, and settle in for a night of TV well worth watching...
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London: Families Talk About Treatment Trials
19
November 2010.
Autosomal-dominant Alzheimer's and Huntington's disease family representatives spoke or showed videos about treatment trials...
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London: What Regulators Say About Trials in Familial AD
18
November 2010.
Eight EMA officials and nine FDA officials took part in a discussion about preclinical trials in autosomal-dominant AD...
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London: What, No Argument? Speakers Agree on Trials for Familial AD
17
November 2010.
Part 2 of Alzforum’s coverage continues with what scientists from inside and outside DIAN said about the prospect of such pre-symptomatic trials...
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London: Europe-U.S. Regulators Mull Prevention Trial in Familial AD
16
November 2010.
The charge of this meeting was to begin a dialogue toward the shared goal of offering therapeutic treatment and prevention trials to families with autosomal-dominant AD...
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DIAN Dispatch from Hawaii: Glimpse at Data, Push for Trials
13
July 2010.
Leaders of DIAN gathered to brief each other to present to some 30 pharmaceutical industry scientists the first cut of baseline data from this ongoing biomarker study...
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DIAN Dispatch From Hawaii: After Slow Start, Network Is Humming
12
July 2010.
After more than a year of rumbling to life, the Dominantly Inherited Alzheimer’s Network (DIAN) has kicked into gear and is now enrolling research participants at a healthy clip...
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Research Brief: Auguste D.'s Mutation Identified?
20
May 2010.
Scientists propose that Auguste Deter, the first identified Alzheimer disease patient, carried the N141I presenilin-2 mutation...
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Phoenix: For Shared Prevention Trials, Devil Is in the Details
2
March 2010.
In Phoenix, senior industry and academic scientists, and regulatory and statistical advisers, dug deep into the details of a proposed pre-symptomatic trials initiative...
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Phoenix: Trials in Colombia and the U.S. for Those at Highest Risk?
1
March 2010.
Researchers have laid out a vision for pre-symptomatic treatment trials that emphasize use of biomarkers to evaluate investigational drugs...
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Phoenix: Can Alzheimer’s Prevention Initiative Break a Catch-22?
26
February 2010.
The Alzheimer’s Prevention Initiative is a proposal to get serious about Alzheimer disease prevention research...
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Phoenix: Vision of Shared Prevention Trials Lures Pharma to Table
25
February 2010.
On 26 January 2010, at an ordinary airport hotel in Phoenix, Arizona, an extraordinary gathering unfolded...
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ARF Notable Book: The Thousand Mile Stare, by Gary Reiswig
19
January 2010.
Through their research participation, the Reiswig extended family made possible the identification of presenilin 2 on chromosome 1...
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St. Louis: An eFAD Prevention Trial—One Man’s View
1
November 2009.
DIAN was founded with the hope that its participating families could be offered a prevention trial and/or treatment trial before too long...
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St. Louis: Imaging Preclinical AD—Can You See it Coming in the Brain?
30
October 2009.
At the 7th Leonard Berg Symposium, brain imaging researchers of various stripes took stock of what brain imaging tells the field about the preclinical period of Alzheimer disease...
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St. Louis: Is Rare Familial Alzheimer’s a Model for the Millions?
28
October 2009.
One question that pervaded the 7th Leonard Berg Symposium is whether dominantly inherited Alzheimer disease really is the same disease as the common late-onset forms...
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St. Louis: Biomarkers Pre-dementia—Like eFAD, Like LOAD?
27
October 2009.
As throughout this conference, talks toggled between what’s known in LOAD and eFAD, comparing all the while how well knowledge on these forms of AD matches up...
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St. Louis: Cognition Pre-dementia—Like eFAD, Like LOAD?
26
October 2009.
At the 7th Leonard Berg Symposium scientists and patient advocates came together to exchange the latest news on detecting disease presymptomatically...
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