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ARF Notable Book: The Thousand Mile Stare, by Gary Reiswig
19
January 2010.
Through their research participation, the Reiswig extended family made possible the identification of presenilin 2 on chromosome 1...
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St. Louis: An eFAD Prevention Trial—One Man’s View
1
November 2009.
DIAN was founded with the hope that its participating families could be offered a prevention trial and/or treatment trial before too long...
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St. Louis: Imaging Preclinical AD—Can You See it Coming in the Brain?
30
October 2009.
At the 7th Leonard Berg Symposium, brain imaging researchers of various stripes took stock of what brain imaging tells the field about the preclinical period of Alzheimer disease...
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St. Louis: Is Rare Familial Alzheimer’s a Model for the Millions?
28
October 2009.
One question that pervaded the 7th Leonard Berg Symposium is whether dominantly inherited Alzheimer disease really is the same disease as the common late-onset forms...
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St. Louis: Biomarkers Pre-dementia—Like eFAD, Like LOAD?
27
October 2009.
As throughout this conference, talks toggled between what’s known in LOAD and eFAD, comparing all the while how well knowledge on these forms of AD matches up...
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St. Louis: Cognition Pre-dementia—Like eFAD, Like LOAD?
26
October 2009.
At the 7th Leonard Berg Symposium scientists and patient advocates came together to exchange the latest news on detecting disease presymptomatically...
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St. Louis: The Family View—What Do Study Volunteers Want From DIAN?
24
October 2009.
When do researchers get to hear from study participants how deeply their families have struggled for decades and what kinds of services would make studies worth their while?...
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St. Louis: Scientists, Families Target Preclinical Detection, Trials
23
October 2009.
Earlier this month, researchers met to devote two intense days of talks and discussion to their goal of presymptomatic detection of Alzheimer disease...
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More AD Genetics—A Familial Hit from the ADAMs Family
12
August 2009.
Genomewide association studies reported by two groups converged on three hits for sporadic Alzheimer disease (AD), ApoJ, CR1, and PICALM...
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News Brief: HBO’s Alzheimer’s Project Debuts on Mother’s Day
8
May 2009.
For the past two years, HBO’s award-winning documentary team has been filming and editing a massive project on Alzheimer disease...
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DIAN Part 3: Genetic and Data Protection for Volunteers
18
November 2008.
DIAN asks a lot of its study volunteers...
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DIAN Part 2: The Science, Inner Workings of the Network
17
November 2008.
Scientifically, the Dominantly Inherited Alzheimer Network (DIAN) will test three hypotheses...
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DIAN: Registry for eFAD to Chart Alzheimer’s Preclinical Decade
13
November 2008.
The rarest kind of Alzheimer disease (AD)—the autosomal-dominant form that runs in families—has long been marked by its untapped opportunities...
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Spain Offers Study for Families With Monogenetic Dementia, eFAD
14
October 2008.
Interest in families stricken with autosomal-dominant Alzheimer disease has intensified in the past few years...
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Paper Alert: PS1 Mutations Jinx Microglia Support for Neurogenesis
5
September 2008.
Researchers report a new role for certain presenilin-1 mutations that cause early-onset familial Alzheimer disease (eFAD)...
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eFAD News: Biomarkers May Help Pinpoint Disease Onset
26
July 2008.
People affected by early-onset familial forms (eFAD) often wonder how discoveries apply to them...
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Alzheimer Activism: How To Modernize Clinical Trials?
31
March 2008.
On March 13, Alzheimer disease activist groups met with representatives from the FDA, clinicians, and industry leaders to discuss ways to improve clinical trials for candidate AD drugs...
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Alzheimer’s, Dementia, and Driving: A Difficult Decision
5
November 2007.
The scenario is all too common: a person with dementia can no longer drive safely, yet family members are reluctant to take away the keys...
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Genetic Testing in the Clinic: What to Do With Knowledge?
21
September 2007.
The deeper we dive into the post-genomic era, the murkier appear the issues surrounding genetic testing and its role in medicine...
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Do "Silent" Seizures Cause Network Dysfunction in AD?
7
September 2007.
In the September 6 Neuron, researchers present electroencephalography (EEG) recordings...
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eFAD Research Surprise: In Mutation Carriers, Amyloid Starts in Striatum
7
June 2007.
The striatum does not have a place of notoriety in Alzheimer disease research...
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Movie Alert: Acclaimed Film About Early-onset AD Debuts in New York
17
May 2007.
No eye-popping action scenes, no happy ending...
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The Value of Biomarkers—Diagnosis and Genetic Screens
17
March 2007.
Much hope rides on the diagnostic and prognostic ability of biomarkers, exemplified by...
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Beyond γ-Secretase: FAD Mutations Affect Calcium Channel via Lipid Messenger
8
December 2006.
Mutations in presenilin associated with familial Alzheimer disease perturb calcium signaling in cells. In particular, some mutations suppress...
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Paper Alert: Ramping Up FAD Mutations Puts Mouse Pathology in Overdrive
12
October 2006.
If doubling the number of FAD mutations can exacerbate Aβ pathology, what about...
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