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Alzheimer Activism: How To Modernize Clinical Trials?
31
March 2008.
On March 13, Alzheimer disease activist groups met with representatives from the FDA, clinicians, and industry leaders to discuss ways to improve clinical trials for candidate AD drugs...
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Alzheimer’s, Dementia, and Driving: A Difficult Decision
5
November 2007.
The scenario is all too common: a person with dementia can no longer drive safely, yet family members are reluctant to take away the keys...
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Genetic Testing in the Clinic: What to Do With Knowledge?
21
September 2007.
The deeper we dive into the post-genomic era, the murkier appear the issues surrounding genetic testing and its role in medicine...
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Do "Silent" Seizures Cause Network Dysfunction in AD?
7
September 2007.
In the September 6 Neuron, researchers present electroencephalography (EEG) recordings...
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eFAD Research Surprise: In Mutation Carriers, Amyloid Starts in Striatum
7
June 2007.
The striatum does not have a place of notoriety in Alzheimer disease research...
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Movie Alert: Acclaimed Film About Early-onset AD Debuts in New York
17
May 2007.
No eye-popping action scenes, no happy ending...
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The Value of Biomarkers—Diagnosis and Genetic Screens
17
March 2007.
Much hope rides on the diagnostic and prognostic ability of biomarkers, exemplified by...
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Beyond γ-Secretase: FAD Mutations Affect Calcium Channel via Lipid Messenger
8
December 2006.
Mutations in presenilin associated with familial Alzheimer disease perturb calcium signaling in cells. In particular, some mutations suppress...
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Paper Alert: Ramping Up FAD Mutations Puts Mouse Pathology in Overdrive
12
October 2006.
If doubling the number of FAD mutations can exacerbate Aβ pathology, what about...
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Presenilins Open Escape Hatch for ER Calcium
9
September 2006.
A paper out today in Cell proposes a novel role for presenilins in calcium signaling...
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Treatment Trends: Tapping Stem Cells, DNA, and RNA to Save Neurons
31
July 2006.
Stem cells and RNA interference offer the latest and, to some, the greatest hope for novel therapies to fight neurodegenerative diseases...
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Linking APP to Apoptosis—p53 Does the Trick
12
June 2006.
The tumor suppressor and apoptotic transcription factor p53 has been linked to Alzheimer disease in numerous ways, but perhaps the most direct link is...
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Does It Fly? Age of Onset in PS-linked FAD Primarily Determined by Mutations
27
May 2006.
All presenilin mutations are not created equal. While over 130 mutations in the presenilin-1 (PS1) gene cause...
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Protease or Not?—More to Presenilin Toxicity than Meets the (Fly's) Eye
8
May 2006.
In the middle of a lively debate about how exactly presenilin (PS) mutations cause Alzheimer disease...
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Mouse of a Different Color: Presenilin Mutations Affect Melanin
13
January 2006.
As the roster of substrates for the γ-secretase protease continues to swell, the presenilin (PS) proteins seem to be...
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APP Double Dose Causes Early-Onset AD
20
December 2005.
For the first time, researchers have identified duplications of the amyloid precursor protein (APP) gene locus...
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Looking outside the Brain for Early Signs of AD
2
October 2005.
The use of gene expression profiling to characterize Alzheimer disease pathology has, unsurprisingly, focused on...
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BRIdging Alzheimer Disease and British/Danish Dementias
29
June 2005.
Amyloids can be formed from many different proteins. In Alzheimer disease (AD), amyloid-β (Aβ) is the culprit, but in other diseases it can be...
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Divergent Roles for PS1, PS2: Not All γ-Secretases Are Created Equal
9
June 2005.
Presenilins make up the catalytic core of the γ-secretase protease complex, and are infamous for their role in...
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The Theology of Aβ: Presenilins Giveth, and They Taketh Away
20
May 2005.
Dogma holds that presenilins in the γ-secretase complex beget amyloid-β (Aβ) peptides by cleaving the membrane-bound β amyloid precursor protein (AβPP). But new results show...
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A New BACE for Immunotherapy
16
May 2005.
Immunotherapy, through either passive or active immunization, remains a viable and aggressively pursued strategy for...
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Familial Alzheimer's Presenilin Gene Perturbs Neurogenesis?
16
July 2004.
Mutations in presenilin could contribute to the memory loss of Alzheimer's disease by perturbing hippocampal neurogenesis...
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Get Out the Rulers—Stunted Dendrites May Flag Early Alzheimer's
14
May 2004.
Stunted dendritic arbors in a subpopulation of hippocampal granule cells are an early sign of Aβ-induced damage, according to a new study of transgenic PDAPP mice...
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The Senility-Presenilin Connection Turned Upside Down
2
April 2004.
Surprising as it may seem, presenilins—the enzymes at the heart of the proteolytic γ-secretase complex that unleashes Aβ peptides—are essential to prevent age-related cognitive deficits and neurodegeneration...
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New Orleans: Symposium Probes Why Synapses Are Suffering
25
November 2003.
Are you sometimes tempted to view APP and presenilin merely as raw material and machine for Aβ production, respectively? If so, think again, because that narrow spotlight is opening up to a broader understanding of how these two proteins function and might contribute to Alzheimer’s...
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