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product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
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Name:
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Sabeluzole
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Other Names:
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R58735
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Development Status:
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investigational in U.S.
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FDA Phase:
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Discontinued
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Pharmacological Role:
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A benzothiazol derivative, shown to enhance memory
function in animals and in normal volunteers. May slow
clinical progression of Alzheimer's disease. It is thought
to be a glutamate antagonist with modulatory effects on
calcium channels. A more recent study proposes that it
exerts neuroprotective effects by a novel mechanism of
stabilizing the neuronal cytoskeleton.
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Notes:
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Reminyl, the brand name used for sabeluzole, now refers to
the drug galanthamine.
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Mohr E, Nair NP, Sampson M, Murtha S, Belanger G, Pappas
B, Mendis T. Treatment of Alzheimer's disease with
sabeluzole: functional and structural correlates.
Clin Neuropharmacol. 1997 Aug;20(4):338-45. Abstract
Geerts H, Nuydens R, De Jong M, Cornelissen F, Nuyens R,
Wouters L. Sabeluzole stabilizes the neuronal cytoskeleton.
Neurobiol Aging. 1996 Jul-Aug;17(4):573-81. Abstract
Aldenkamp AP, Overweg J, Smakman J, Beun AM, Diepman L,
Edelbroek P, Gutter T, Mulder OG, vt Slot B, Vledder B.
Effect of sabeluzole (R 58,735) on memory functions in
patients with epilepsy. Neuropsychobiology. 1995;32(1):37-
44. Abstract
Pauwels PJ, Van Assouw HP, Peeters L, Moeremans M, Leysen
JE. Chronic treatment with sabeluzole protects cultured
rat brain neurons from the neurotoxic effects of
excitatory amino acids. Synapse. 1992 Dec;12(4):271-80.
Abstract
Geerts H, Nuydens R, Nuyens R, Cornelissen F, De Brabander
M, Pauwels P, Janssen PA, Song YH, Mandelkow EM.
Sabeluzole, a memory-enhancing molecule, increases fast
axonal transport in neuronal cell cultures. Exp Neurol.
1992 Jul;117(1):36-43. Abstract
De Deyn PP, Van de Velde V, Verslegers W, Saerens J,
Pickut BA, Clincke B, Woestenborghs R, Van Peer A. Single-
dose and steady-state pharmacokinetics of sabeluzole in
senile dementia of Alzheimer type patients. Eur J Clin
Pharmacol. 1992;43(6):661-2.
Abstract
Nikolov R, Scheller D, Nikolova M. Study on the cerebral
effects of sabeluzole. Methods Find Exp Clin Pharmacol.
1991 Jul-Aug;13(6):385-90. Abstract
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