| NAME:
AAB-001
|
| OTHER NAMES:
Bapineuzumab, Humanized monoclonal anti-Aβ antibody
|
| FDA PHASE:
Phase III
|
| MECHANISMS:
Designed to bind and remove the Aβ peptide that accumulates in the brain.
|
| ROLE IN ALZHEIMER'S DISEASE:
Wyeth and Elan are currently running a phase 2 trial in
200 patients with mild to moderate AD with humanized
monoclonal antibody Bapineuzumab. It is being conducted at
about 30 sites in the U.S., an 18-month, multi-dose study
at one-to-one randomization with placebo. The trial is
designed to assess safety and tolerability, as well as
standard efficacy endpoints (ADAS-Cog, Neuropsychological
Test Battery and Disability Assessment for Dementia), of
multiple ascending doses of Bapineuzumab in subjects. The
18-month trial includes an interim analysis, as well as
data collection on clinical endpoints and biomarkers. A
small amyloid imaging study in Europe is ongoing to
determine whether existing plaques in patients with mild
to moderate AD are reduced while on this potential
therapy.
On 21 May 2007, Elan and Wyeth announced their plans to
initiate phase 3 clinical trials of Bapineuzumab. The
decision to launch phase 3 studies prior to the conclusion
of the ongoing phase 2 was based on the totality of the
accumulated clinical data from phase 1, phase 2 and a 4.5-
year follow-up study of those patients involved in the
original AN-1792 trial.
|
|
| NAME:
ABT 418
|
| FDA PHASE:
Discontinued
|
|
|
| NAME:
ACC-001
|
| FDA PHASE:
Phase I
|
| ROLE IN ALZHEIMER'S DISEASE:
Elan research indicates that antibodies specific for Aβ
peptide can cross
the
blood-brain barrier and act directly in the central
nervous system to induce
plaque clearance. These findings suggest that this novel
method may clear
plaques in human patients.
|
|
|
| NAME:
Acetyl-l-carnitine HCI
|
| OTHER NAMES:
ALCAR
|
| FDA PHASE:
Discontinued
|
| ROLE IN ALZHEIMER'S DISEASE:
Lessen cognitive deterioration
|
|
|
| NAME:
AF 102B
|
| OTHER NAMES:
cevimeline HCL, Evoxac™
|
| FDA PHASE:
Discontinued
|
| ROLE IN ALZHEIMER'S DISEASE:
Improve neuronal responsiveness to neurotrophic factors.
|
|
|
| NAME:
Alpha-tocopherol
|
| OTHER NAMES:
Vitamin E
|
| ROLE IN ALZHEIMER'S DISEASE:
Thought to prevent brain cell damage by destroying toxic
free radicals.
|
|
|
| NAME:
Alzhemed™
|
| OTHER NAMES:
3-amino-1-propanesulfonic acid, 3-aminopropylsulfonic acid, 3-APS, homotaurine, NC-531, Tramiprosate
|
| FDA PHASE:
Phase III
|
| MECHANISMS:
Designed to cross the blood-brain barrier, tramiprosate is an amyloid-β antagonist.
|
| ROLE IN ALZHEIMER'S DISEASE:
Tramiprosate was designed to prevent amyloid formation and
deposition in the brain, and thus modify the course of AD.
It has been tested extensively in clinical trials in both
the U.S. and the EU for mild to moderate AD. The recent
U.S. Phase 3 trial is widely considered to have failed
(see ARF related news story and comments). The EU
Phase 3 trial has been discontinued (see ARF
related news story). Recent published evidence
demonstrates that tramiprosate alters tau aggregation (see
Santa-Maria et
al., 2007 and comments and ARF
related news story).
|
|
|
| NAME:
AN 1792
|
| OTHER NAMES:
AIP 001
|
| FDA PHASE:
Discontinued
|
| ROLE IN ALZHEIMER'S DISEASE:
AN-1792 is a synthetic form of the 42 amino acid beta
amyloid peptide. It is hypothesized that immunization with
AN-1792 can prevent or reverse the development of the
neuropathological hallmarks of Alzheimer's diseases,
including extensive amyloid plaque formation, neuritic
dystrophy, synaptic loss and gliosis.
|
|
|
| NAME:
Atorvastatin
|
| OTHER NAMES:
Lipitor™
|
| FDA PHASE:
Phase II/IIa/IIb
|
| ROLE IN ALZHEIMER'S DISEASE:
A multi-center analysis of over 60,000 patients indicated
a decreased prevalence of AD in patients taking lovastatin
and pravastatin, two statin drugs commonly used in lowering
cholesterol. Several possible roles of statins in AD have
been proposed, see our drug sheet on statins.
|
|
|
| NAME:
AZD3480
|
| OTHER NAMES:
ispronicline, TC-1734
|
| FDA PHASE:
Phase II/IIa/IIb
|
| MECHANISMS:
AZD3480 is an orally active novel neuronal nicotinic agonist with high selectivity for neuronal α4β2 nicotinic (nAChR) receptors.
|
| ROLE IN ALZHEIMER'S DISEASE:
AZD3480 has been tested in normal elderly human subjects
with age-associated memory impairment (Dunbar et al.,
2007) in a double-blind, placebo-controlled cross-over
study, which tested ascending oral doses in the range of
50-150 mg given as a single morning dose for a period of 3
weeks. Cognitive function was assessed with the
computerized Cognitive Drug Research (CDR) test battery. A
peak in beneficial cognitive effect was observed in
attention and episodic memory, at 50 mg dose, although
beneficial effects were observed across the dose range.
|
|
|
| NAME:
Besipirdine HCl
|
| OTHER NAMES:
HP 749
|
| FDA PHASE:
Discontinued
|
|
|
| NAME:
Beta- & Gamma-Secretase Inhibitors
|
| FDA PHASE:
Preclinical
|
| ROLE IN ALZHEIMER'S DISEASE:
Beta-secretase and gamma-secretase are two proteases that
cleave amyloid precursor protein, producing amyloid
beta-peptide. Inhibiting these enzymes might reduce the
burden of amyloid beta-peptide in AD pateints' brains,
which might then slow the progression of the disease.
|
|
|
| NAME:
Cerebrolysin
|
| FDA PHASE:
Preclinical
|
| MECHANISMS:
Neuroprotection, neurotrophic agent, promotes neurogenesis, may decrease rate of apoptosis.
|
| ROLE IN ALZHEIMER'S DISEASE:
Cerebrolysin is a peptide-based drug product supporting
the survival, stability, and function of neurons.
Cerebrolysin decreases amyloid production, promotes
synaptic repair, and improves cognitive and behavioral
performance.
|
|
|
| NAME:
Clioquinol
|
| OTHER NAMES:
iodochlorhydroxyquin, PBT-1
|
| FDA PHASE:
Discontinued
|
| MECHANISMS:
metal-protein-attenuation
|
| ROLE IN ALZHEIMER'S DISEASE:
Clioquinol inhibits zinc and copper ions from binding to
Aβ, thus promoting the solubilization and clearance
of Aβ. A pilot phase II clinical trial suggests that
clioquinol improves cognition and lowers plasma levels of
Aβ42 in some patients.
|
|
|
| NAME:
COGNIShunt™
|
| FDA PHASE:
Phase II/IIa/IIb
|
| ROLE IN ALZHEIMER'S DISEASE:
Cerebrospinal fluid production and turnover diminish with
age and may be further diminished in Alzheimer's disease.
Flow-regulated drainage of CSF may reduce the accumulation
of proteins such as tau and β-amyloid and other inflammatory
mediators implicated in AD.
|
|
|
| NAME:
CX516
|
| OTHER NAMES:
Ampalex
|
| FDA PHASE:
Phase II/IIa/IIb
|
| MECHANISMS:
AMPAkines
|
| ROLE IN ALZHEIMER'S DISEASE:
May improve cognitive function in AD patients by
pharmacologically stimulate AMPA receptor-mediated
synaptic responses. Reported to enhance memory performance
in healthy elderly subjects.
|
|
|
| NAME:
Dapsone
|
| OTHER NAMES:
Avlosulfon
|
| FDA PHASE:
Phase II/IIa/IIb
|
| ROLE IN ALZHEIMER'S DISEASE:
As an anti-inflammatory drug, Dapsone might slow the
progression of Alzheimer Disease.
|
|
|
| NAME:
Dimebon
|
| OTHER NAMES:
3,6-dimethyl-9-(2-methyl-pyridyl-5)-ethyl-1,2,3,4-tetrahydro-γ-carboline dihydrochloride
|
| FDA PHASE:
Phase II/IIa/IIb
|
| MECHANISMS:
Has activity as an inhibitor of cholinesterase and NMDA receptors. Inhibits neuronal death, potentially by mitochondrial-mediated inhibition of apoptosis.
|
| ROLE IN ALZHEIMER'S DISEASE:
Cognitive enhancer, shown to have efficacy in all measures
of cognition and behavior in mild-to-moderate Alzheimer
Disease patients. In vitro Dimebon protected primary
neuron cultures against Aβ toxicity
(EC50=25 μM) and inhibits both
acetylcholinesterase (I50=42 μM) and
butyrylcholinesterase (IC50=7.9 μM), as well as
inhibiting NMDA receptors (IC50 range of 10-70
μM) (Bachurin et al., 2001; Grigoriev et al., 2003).
Neuroprotective effects of Dimebon has also been observed
in a transgenic Drosophila model of Huntington
Disease, protecting photoreceptor neurons against death
induced by human Huntington protein (htt) (unpublished
data, Medivation disclosure).
In a recent clinical trial in mild-to-moderate AD in
Russia (completed summer 2006), Dimebon demonstrated
positive clinical efficacy in cognition and behavior using
five independent measures of cognitive impairment.
|
|
|
| NAME:
Docosahexanoic acid (DHA)
|
| OTHER NAMES:
Omega 3 fatty acids
|
| FDA PHASE:
Phase III
|
| MECHANISMS:
DHA is a major component of neuron membranes and has multiple functions, including modulation of presenilin.
|
| ROLE IN ALZHEIMER'S DISEASE:
Alzheimer disease patients have significantly lower DHA
levels compared to control subjects, and serum cholesteryl
ester-DHA levels are progressively reduced with severity
of clinical dementia (Tully et al., 2003). A previous
omega-3 fatty acid treatment clinical trial in Sweden
demonstrated a significant (P <.05) reduction in MMSE
decline rate in the omega-3 fatty acid-treated group
compared with the placebo group in a subgroup of patients
with a very mild cognitive dysfunction, observed at 6 and
12 months (Freund-Levi et al., 2006).
|
|
|
| NAME:
Donepezil
|
| OTHER NAMES:
Aricepts™
|
| FDA PHASE:
FDA approved
|
| MECHANISMS:
cholinesterase inhibitors
|
| ROLE IN ALZHEIMER'S DISEASE:
Improves cognition, global function, and activities of
daily living.
|
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