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Important Notice: The Forum does not endorse any medical product or therapy. ALL medications and supplements should be taken ONLY under the supervision of a physician, due to the possibility of side-effects, drug interactions, etc.

SRIs are now considered by many the first line drug for depression in the elderly, because of their favorable side effect profile (however, SRIs infrequently cause nausea, vomiting, agitation, akathisia, sexual dysfunction, and appetite changes).

Of special concern to clinicians in the context of the elderly is the many interactions SRIs have with other medications.

(see Reynolds, C.F. III, 1997)