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Important Notice: The Forum does not endorse any medical
product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
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Name:
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LU25-109
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Development Status:
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investigational in U.S.
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FDA Phase:
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Discontinued
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Pharmacological Role:
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Lu 25-109 is a functionally selective partial M1 agonist
with M2/M3 antagonist properties.
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Thal LJ, Forrest M, Loft H, Mengel H. Lu 25-109, a
muscarinic agonist, fails to improve cognition in
Alzheimer's disease. Lu25-109 Study Group. Neurology. 2000
Jan 25;54(2):421-6.
Abstract
Sanchez C, Arnt J, Didriksen M, Dragsted N, Moltzen Lenz
S, Matz J. In vivo muscarinic cholinergic mediated effects
of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro.
Psychopharmacology (Berl). 1998 Jun;137(3):233-40. Abstract
Muller D, Wiegmann H, Langer U, Moltzen-Lenz S, Nitsch RM.
Lu 25-109, a combined m1 agonist and m2 antagonist,
modulates regulated processing of the amyloid precursor
protein of Alzheimer's disease. J Neural Transm. 1998;105
(8-9):1029-43. Abstract
Sramek JJ, Forrest M, Mengel H, Jhee SS, Hourani J, Cutler
NR. A bridging study of LU 25-109 in patients with
probable Alzheimer's disease. Life Sci. 1998;62(3):195-202. Abstract
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