Curcumin has been shown to reduce amyloid plaque and
accumulated Aβ in APP transgenic mice and reduces oxidative
damage, inflammatory response and cognitive deficits
by infused Aβ into rat CNS (reviewed in Cole et al 2007).
Reviewed extensively by Frautschy and Cole (2010), curcumin
has been shown bind and clear Aβ plaques and oligomers in
animal models, inhibit tau aggregation, limit inflammatory
cytokine production, and protect against oxidative damage.
Longvida™ is a solid-lipid curcumin particle formulation
that increases bioavailability. Natural curcumin has
limited bioavailability and brain permeability due to poor
water solubility and rapid metabolism.