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Abnormal Mitochondrial Dynamics—Early Event in AD, PD?
5 February 2010. Mitochondria take the stage in three recent papers...
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Think You Know γ-secretase and p25? Think Again
5 February 2010. There are times in the course of scientific enterprise when researchers must re-evaluate their hypotheses in the face of new, unexpected data...
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Going Wild About the Latest TDP-43 Mouse Models
4 February 2010. The new animal models for TDP-43 proteinopathies, a series of related neurodegenerative diseases, are coming out at a fast and furious rate...
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Shape-shifting Prions: Infectious Recombinant and Myelin-Minding Normal
3 February 2010. The cellular prion protein has received a lot of attention recently for its potential role in amyloid-β (Aβ) toxicity...
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In the spotlight
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AlzSWAN in the News
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From the department of kvelling: Our very own AlzSWAN knowledge base is featured in a Nature news story about computations tools to help scientists navigate the scientific literature. Nature interviewed Alzforum members about how they are using AlzSWAN. The article includes nice images of our graphical mapping tool. Kudos to the AlzSWAN team! Image credit: Nature Publishing Group |
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Copper Mountain Moguls—Struggling to Get Over Aβ
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Like skiers on the mogul run, it seems everywhere Alzheimer disease researchers turn, there’s that bump to get over—Aβ. The harder the field tries to avoid the peptide, as in last week’s Keystone Symposium “Alzheimer’s Disease Beyond Aβ” held at the ski town of Copper Mountain, Colorado, the more imposing it appears. Organized by Tony Wyss-Coray and JoAnne McLaurin, the symposium was conceived to consider alternative therapeutic approaches to targeting Aβ, a strategy that |
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has so far failed to deliver. But as one researcher aptly framed it, “beyond” could mean both apart from, or downstream of, Aβ. Both interpretations were evident during the symposium, where most presenters couldn’t help mentioning Aβ. Check this space for Tom Fagan’s stories on the news, Aβ-esque or otherwise. Image credit: Tom Fagan
 Can CREB Save Memory?
Knight Vision—SIRT1 Aids ADAM10, Slays Aβ
Rat-a-tat—New Model Comes a Knockin’
Death and Trophin Receptors—New Insight, New Drugs?
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What's New
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Conferences - Posted 9 February 2010
Alzheimers New Zealand Conference 2010: 6-8 May 2010, Michael Fowler Centre, Wellington, New Zealand. |
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Desperately Seeking Research Participants - Posted 8 February 2010
Non-invasive, Non-drug Dementia Clinical Trial by Quietmind Foundation, a nonprofit research and training organization. |
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Comments - Posted 5 February 2010
Read remarks by Mark A. Smith, Hyoung-gon Lee, Rudy Castellani, George Perry, Xiongwei Zhu about Roe CM et al.
PAPER: Cancer linked to Alzheimer disease but not vascular dementia. |
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Comments - Posted 5 February 2010
Read remarks by Xiongwei Zhu about Zhao XL et al.
PAPER: Expression of beta-amyloid Induced age-dependent presynaptic and axonal changes in Drosophila. |
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Comments - Posted 5 February 2010
Read remarks by Bingwei Lu about Geisler S et al.
PAPER: PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. |
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Comments - Posted 5 February 2010
Read remarks by Bingwei Lu about Zhao XL et al.
PAPER: Expression of beta-amyloid Induced age-dependent presynaptic and axonal changes in Drosophila. |
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Comments - Posted 5 February 2010
Read remarks by Lucia Chavez-Gutierrez about Zhao G et al.
PAPER: {gamma}-Secretase Composed of PS1/Pen2/Aph1a Can Cleave Notch and Amyloid Precursor Protein in the Absence of Nicastrin. |
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Jobs - Posted 5 February 2010
Director, Geriatric Research, Education and Clinical Center (GRECC): VA Puget Sound Health Care System & Department of Psychiatry & Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington. |
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