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Research News
 
Experts Slam Marketing of Tramiprosate (Alzhemed) as Nutraceutical
10 October 2008. The Canadian pharmaceutical company Bellus Health has begun to sell the would-be prescription drug tramiprosate over the counter as a nutritional supplement...
 
Microglia in ALS: Helpful, Harmful, or Neutral?
10 October 2008. In the complex interplay between neurons and glia during ALS, microglia have been painted as both toxin-producing killers and protective defenders...
 
Newest Stem Cell Approaches Abandon Viruses, Tap Testes
9 October 2008. A recent flurry of papers offer safer, less controversial methods for generating host-specific stem cells...
 
TBPB or Not to Be—The Latest on Muscarinic Receptor Agonists
8 October 2008. Key roles in modulating cognition and behavior made the M1 muscarinic acetylcholine receptor (mAChR) a prime target for AD drug developers...
 
GO TO ALL RESEARCH NEWS  
 
 
In the spotlight

Interview with Deborah Blacker, the Brain Behind AlzRisk
Deborah Blacker
What lifestyle factors influence one’s risk of getting Alzheimer disease? For the public, the answer seems to depend on the latest study. One study exhorts the reader to eat more fresh fruits and vegetables, while the next warns about metabolic disorder. Even Alzheimer’s experts find it challenging to keep track. What does the research really show over dozens of studies on tens of thousands of people? To help answer this question, Alzforum teamed up with Deborah Blacker and colleagues to launch AlzRisk. Akin to AlzGene, which catalogs genetic risk
factors, AlzRisk aims to provide a comprehensive, unbiased, centralized, publicly available, and regularly updated collection of epidemiologic reports that evaluate environmental (i.e., non-genetic) risk and protective factors for Alzheimer disease (AD) in well-defined study cohorts.

Eligible publications are identified through contact with each cohort study supplemented by a systematic review of the literature. Meta-analyses and commentary on the relationship of the risk factor to AD as well as upon study results are also available. The database is in development and currently presents data for vitamin E supplement use and diabetes mellitus. Additional risk factors will be added in the coming year. To learn more about the history and scope of AlzRisk, read Tom Fagan’s interview with Blacker, who holds positions at Massachusetts General Hospital, Charlestown, and the Harvard School of Public Health, Boston. We welcome your feedback.

AD Social Poetry Slam: Give Us Your Rhymes and Win a $$ Prize!

It's the Alzheimer Social!
Our chance to shine, divine, and generally feel fine.
Those of you, the secret bards,
Wishing your lyrics, your rhymes, your chimes will gather cheer,
Now's the chance to show your literary skill,
Prancing, romancing, and swing dancing from line to line... (Read the entire poem)

This year's AD Social at the Society for Neuroscience features a Poetry Slam. Join us Tuesday, 18 November, 6-7 p.m. (room TBD). Find out more about this event.

 
 
What's New

Grants Update - Posted 10 October 2008
Program: Replication and Fine-Mapping Studies for the Genes Environment and Health Initiative (GEI)(R01)
Funds: $400K for 1 yr
Deadline(s): Letters of Intent Receipt Date(s): October 24, 2008; Application Receipt Date(s): December 01, 2008
 
Grants Update - Posted 10 October 2008
Program: Brookdale Foundation Leadership in Aging Fellowship Program 2009
Funds: $125K/yr for 2 yrs.
Deadline(s): Application Deadline: November 6, 2008
 
Jobs - Posted 10 October 2008
Postdoctoral Research Associate: Nathan Kline Institute, Orangeburg, New York.
 
Current Hypotheses - Posted 9 October 2008
Read "Aβ and the Neurotrophin Receptor p75" by Rudolf Bloechl, independent investigator, Germany.
 
Jobs - Posted 9 October 2008
Staff Associate: Gertrude Sergievsky Center, Columbia University Medical Center, New York, New York.
 
Comments - Posted 8 October 2008
Read remarks by Jurgen Gotz about Calvo AC et al.
PAPER: Determination of protein and RNA expression levels of common housekeeping genes in a mouse model of neurodegeneration.
 
Comments - Posted 8 October 2008
Read remarks by Allan Levey about Jones CK et al.
NEWS: TBPB or Not to Be—The Latest on Muscarinic Receptor Agonists
 
Comments - Posted 8 October 2008
Read remarks by Abraham Fisher about Jones CK et al.
NEWS: TBPB or Not to Be—The Latest on Muscarinic Receptor Agonists

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An up-to-date collection of all published genetic association studies.
ADPD 2007
9th International AD/PD Conference
March 11-15, 2009
Prague, Czech Republic. Abstract submission deadline: Wednesday, October 15, 2008. See details.

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Alzheimer Research Forum: A Knowledge Base and E-Community for AD Research [.pdf]: Read the chapter by June Kinoshita and Gabrielle Strobel published in Alzheimer: 100 Years and Beyond (Springer, 2006).
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Download Powerpoint Presentations created by top experts in neurodegenerative disease research. Available for educational or personal use. Edited by Daniel M. Michaelson, PhD, and Tobias Hartmann, PhD.

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The Drug Development Company Database and Tutorial represent the collaborative efforts of the Alzheimer's Drug Discovery Foundation (ADDF)/Institute for the Study on Aging (ISOA) and the Alzheimer Research Forum. Our thanks to ADDF, Jens Eckstein, and the Advisory Board for bringing this project to fruition.
ISOA
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Compared to cancer, why do so few people with AD participate in drug trials?
 
Doctors fail to point out opportunities
 
Caregivers don't want added bother
 
Informed consent is tricky
 
People don't understand the need
 
People can't easily access
 
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