This conference will focus on cutting-edge developments in catecholamine research from a broad range of approaches, from molecular biology to cellular physiology to behavior and clinical studies. One of the characteristics of the field is that neuronal systems using catecholamines have much in common, although investigators who focus on particular catecholamines or on different actions of the same catecholamine are often unaware of complementary aspects of catecholamine research. Continued progress will require increasingly integrated approaches in studies of catecholamine biology, function and dysfunction. Recent years have also seen a tremendous advance in understanding of neuropsychiatric and neurological disorders, including drug abuse, affective disorders, and diseases associated with catecholamine neuron degeneration such as Parkinson's and Alzheimer's. These new advances will be highlighted to provide a unique opportunity to discuss recent progress in the understanding of how catecholamine systems may contribute to the pathophysiology and treatment of those conditions.