This live symposium will feature presentations by some of the most preeminent leaders in the field of AD research and clinical practice on four major topics: neuroimaging, genetics, therapeutics, and future directions in AD Research. Major advances in research and treatment paradigms over the past 30 years will be discussed, along with discourse on "next-generation" research and development approaches that will mine "Big Data" from cross-disciplinary teams to translate research findings to effective therapeutics for patients with AD.