Animal Models, Molecular and Cell biology, Proteomics, A-beta PP/A-beta
Researcher Bio My research focuses on the molecular events underlying neurodegeneration in Alzheimer's disease (AD). Among other neuropathological features, cortical deposition of an insoluble material, called b-amyloid, occurs in both the aging and the AD-afflicted brain. The main component of the amyloid plaque is a small peptide, the b-amyloid protein. I am interested in identifying the cellular pathways regulating the generation of the b-amyloid protein, and the factors involved in the subsequent neurodegenerative process associated with this peptide.