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| First Name: | Dmitry | | Last Name: | Goldgaber | | Title: | Professor | | Advanced Degrees: | Ph.D. equivalent | | Affiliation: | State University of New York at Stony Brook | | Department: | Psychiatry and Behavioral Science | | Street Address 1: | HSC, T-10 | | City: | Stony Brook | | State/Province: | NY | | Zip/Postal Code: | 11794-8101 | Country/Territory: | U.S.A. | | Phone: | (631)444-1369 | | Fax: | (631)444-7534 | | Email Address: |  |
Disclosure:
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View all comments by Dmitry Goldgaber
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Prion Diseases, Alzheimer Disease, Aging Process, Tauopathies, Neurodevelopmental Disorders (Down syndrome, etc.)
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Diagnosis, Animal Models, Apoptosis/Cell cycle, Neuropathology, Stem cells, Microscopy, Proteomics, Tau/Cytoskeleton, A-beta PP/A-beta, Molecular and Cell biology, Neurobiology, Neuroimmunology, Oxidative Stress, Protein structure/chemistry, DNA microarrays, Signal transduction, Epidemiology, Genetics
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With background in physics and molecular biology spent first 15 years of research in the field of virology. Worked with Bunya- and Arenaviruses, and later with Hantaan viruses. In 1986 discovered and mapped with co-workers the APP gene and since then stayed in the AD field. Lost a bet to John Hardy by discovering the first PrP mutation in CJD (I did not believe that PrP mutations are related to CJD). Showed involvement of proteasome in APP degradation. Correctly predicted the association of ApoE isoforms with amyloid load. Postulated and proved the sequestration hypothesis of Abeta. Made APP movies in real time in live cells. |
See Medline and Web of Science for the most referred papers. |
1) What cause AD in patients without mutated genes?
2) How to cure AD? |
The first paper by A. Alzheimer. |
The origin of non genetic AD. |
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