Researcher Bio Currently a Section Chief in the laboratory of Neurosciences at the National Institute on Aging.
What is the greatest void to date in our knowledge of Alzheimer's Disease? Mechanism of cell damage
What are the top three papers (not yours) you have read recently? Too many to list
If resources were not limited, what research projects would you pursue? I would build a truly useful model of alzheimers disease which would be a useful tool to test the many ocntroversies in the field.
What is your leading hypothesis? Brain cells (neurons) are limited in number irrespective of the cause once lost they don't seem to be replaced. While the brain has some redundancy and plasticity once loss exceeds a certain threshold decline in cognitive function is inevitable.
Identifying ways to prevent, retard the loss, or replace the missing cells would ameliorate the disease symptoms.
What piece of missing evidence would help prove it? The ability to follow cells in vivo over the course of the disease.
What is your fallback position? Since this is a complicated process and we are not yet close to understanding how neurons function in a complicated circuit our fallback position is to try and retard the loss of neurons