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| First Name: | George | | Last Name: | Bartzokis | | Advanced Degrees: | MD | | Affiliation: | UCLA | | Department: | Neurology | Country/Territory: | U.S.A. | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 2 April 2004]
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View all comments by George Bartzokis
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Aging Process, Polyglutamine Disorders (Huntington's, etc.), Alzheimer Disease, Prion Diseases, Neurodevelopmental Disorders (Down syndrome, etc.), Stroke and Trauma, Tauopathies, Parkinson Disease
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Clinical trials, Brain imaging
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Personal:
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No
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Professional:
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No
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Lab:
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No
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Bartzokis G, Sultzer D, Lu PH, Nuechterlein K, Mintz J, Cummings JL. Heterogeneous age-related breakdown of white matter structural integrity: Implications for cortical “disconnection” in aging and Alzheimer’s disease. Neurobiology of Aging 2004 (in press).
Bartzokis G, Tishler TA, Shin I-S, Lu PH, Cummings JL. Brain ferritin iron as a risk factor for age of onset in neurodegenerative diseases. In S LeVine, J Connor, H Schipper (eds), Redox-active Metals in Neurological Disorders. New York: Ann N Y Acad Sci 2004 (in press).
Bartzokis G. Quadratic trajectories of brain myelin content: Unifying construct for neuropsychiatric disorders. Neurobiology of Aging 2004; 49-62.
Bartzokis G. Age-related myelin breakdown: A developmental model of cognitive decline and Alzheimer’s disease. Neurobiology of Aging 2004; 25:5-18.
Bartzokis G, Cummings J, Sultzer D, Henderson VW, Nuechterlein K, Mintz J. White matter structural integrity in aging and Alzheimer’s disease: A magnetic resonance imaging study. Arch Neurol 2003; 60:393-398.
Bartzokis G, Nuechterlein KH, Lu PH, Gitlin M, Rogers S, Mintz J. Dysregulated brain development in adult men with schizophrenia: A magnetic resonance imaging study. Biol Psyciatry 2003; 53-412-421.
Bartzokis G. Schizophrenia: Breakdown in the well regulated lifelong process of brain development and maturation. Neuropsychopharm 2002; 27: 672-683.
Bartzokis G, Beckson M, Lu PH, Nuechterlein K, Edwards N, Mintz J. Age-related changes in frontal and temporal lobe volumes in men: A magnetic resonance imaging study. Arch Gen Psychiatry 2001; 58:461-465.
Bartzokis G. MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer’s and Huntington’s disease. Cellular and Molecular Biology, The Role of Metals in the Brain 2000; 46:821-833.
Bartzokis G, Sultzer D, Cummings JL, Holt LE, Hance DB, Henderson VW, Mintz J. In vivo evaluation of brain iron in Alzheimer’s disease and normal controls using magnetic resonance imaging. Arch Gen Psychiatry 2000; 57:47-53.
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Why age is the overwhelming risk factor |
Use imagign biomarkers to develop treatments that slow brain aging in middle age and thus eliminate Alzheimer's. |
Myelin breakdown underlies brain aging and therefore is the most important modifiable risk factor for Alzheimer's disease. |
Actual clinical trials with existing treatments applied to normal middle age to elderly individuals. |
Use biomarkers to enrich ongoing clinical trial samples with individuals that are mostlikely to benefit from paarticular interventions. |
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