|
|
|
|
|
| First Name: | Paul | | Last Name: | Coleman | | Title: | Professor | | Advanced Degrees: | Ph.D. | | Affiliation: | University of Rochester Medical Center | | Department: | Center on Aging and Developmental Biology | | Street Address 1: | 601 Elmwood Ave. | | City: | Rochester | | State/Province: | NY | | Zip/Postal Code: | 14642 | Country/Territory: | U.S.A. | | Fax: | (585) 273-1132 | | Email Address: |  |
Disclosure:
(view policy)
|
|
|
|
View all comments by Paul Coleman
|
Alzheimer Disease, Aging Process
|
DNA microarrays, Diagnosis, Microscopy, Animal Models, Neuropathology, Proteomics, Tau/Cytoskeleton, Apoptosis/Cell cycle, Neurobiology, Bioinformatics/Statistics, Molecular and Cell biology
|
Ph.D. Univ. Rochester, 1953
1 Lt., US Army Medical Research Lab 53-56
Res.Asst Prof,.Tufts Univ.56-59
Associate M.I.T. Computer Center 57-59
Fellow, Johns Hopkins Medical 59-62
Assoc. Prof. Physiol., U. Maryland 62-67
Professor, Univ. of Rochester 67 - present
Director, Alzheimer Disease Center 90-present
Editor-in-Chief, Neurobiology of Aging 88- present |
Buell & Coleman (1979) Dendritic growth in aged human brain and failure of growth in senile dementia. Science, 206: 854-856.
Eberwine, Yeh, Miyashiro, Cao, Nair, Finnell, Zettle and Coleman (1991) Analysis of gene expression in single neurons. P.N.A.S., 89: 3010-3014.
Callahan & Coleman (1995) Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease. Neurobiol. Aging, 16: 311-314.
Chow, Cox, Callahan, Weimer, Guo and Coleman (1998) Expression profiles of multiple genes in single neurons of Alzheimer's disease. P.N.A.S. 95: 9620-9625.
Morsch, Simon & Coleman (1999) Neurons may live for decades with neurofibrillary tangles. J. Neuropath & Exptl. Neurol., 58: 188-197.
Callahan, Vaules & Coleman (1999) Quantitative decrease in synaptophysin message and increase in cathepsin D message expression in Alzheimer's disease neurons. J. Neuropath & Exptl. Neurol., 58: 275-287.
Callahan, Vaules & Coleman (2002) Progressive reduction of synaptophysin message in single neurons in Alzheimer's disease. J. Neuropath & Exptl. Neurol. In Press.
Yao & Coleman (2002) Deficits in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease. Neurobiol. of Disease. In Press
. |
Description of the entire molecular cascade of AD from first cause(s) to cell death - and the functional neurobiological consequences of the progression of this cascade. |
Not really a hypothesis, but more related to experimental approach: that information derived from single brain cells is more valuable than information derived from homogenates that contain many cell types as well as cells in different stages of disease. |
To work with homogenates. |
|
|
|
|
|
|
Home
