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| First Name: | Cara | | Last Name: | Westmark | | Title: | Assistant Scientist | | Advanced Degrees: | PhD | | Affiliation: | University of Wisconsin | | Department: | Pathology | | Street Address 1: | Waisman Center for Developmental Disabilities | | Street Address 2: | 1500 Highland Avenue | | City: | Madison | | State/Province: | WI | | Zip/Postal Code: | 53705 | Country/Territory: | U.S.A. | | Phone: | 608 262 9730 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 1 September 2004]
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Alzheimer Disease, Neurodevelopmental Disorders (Down syndrome, etc.), Aging Process, Prion Diseases
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Microscopy, Molecular and Cell biology, Neurobiology, Neuropathology, A-beta PP/A-beta, Animal Models, Apoptosis/Cell cycle, Bioinformatics/Statistics, Signal transduction
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My area of expertise is molecular biology, and in
particular, protein/nucleic acid interactions and signal transduction as pertaining to the study of neurodegenerative disorders. My current research project pertains to the translational regulation of
Amyloid Precursor Protein (APP) mRNA by Fragile X Mental Retardation Protein (FMRP). Our preliminary data indicates that FMRP increases the translation of proteins involved in synaptic plasticity after mGluR1-dependent signaling and suggests a link between two neurodegenerative disorders, Alzheimer’s Disease and
Fragile X Syndrome. |
1: Westmark CJ, Ghose R, Huber PW.
Phosphorylation of Xenopus transcription factor IIIA by an oocyte protein kinase CK2.
Biochem J. 2002 Mar 1;362(Pt 2):375-82.
PMID: 11853545 [PubMed - indexed for MEDLINE]
2: Westmark CJ, Malter JS.
Extracellular-regulated kinase controls beta-amyloid precursor protein mRNA decay.
Brain Res Mol Brain Res. 2001 Jun 20;90(2):193-201.
PMID: 11406297 [PubMed - indexed for MEDLINE]
3: Westmark CJ, Malter JS.
Up-regulation of nucleolin mRNA and protein in peripheral blood mononuclear cells by extracellular-regulated kinase.
J Biol Chem. 2001 Jan 12;276(2):1119-26.
PMID: 11042220 [PubMed - indexed for MEDLINE]
4: Westmark CJ, Ghose R, Huber PW.
Inhibition of RNA polymerase III transcription by a ribosome-associated kinase activity.
Nucleic Acids Res. 1998 Oct 15;26(20):4758-64.
PMID: 9753746 [PubMed - indexed for MEDLINE]
5: Rajagopalan LE, Westmark CJ, Jarzembowski JA, Malter JS.
hnRNP C increases amyloid precursor protein (APP) production by stabilizing APP mRNA.
Nucleic Acids Res. 1998 Jul 15;26(14):3418-23.
PMID: 9649628 [PubMed - indexed for MEDLINE] |
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