Researcher Bio Currently (2012) seeking postdoc level research post 2011 PhD Mathematical Biology & Biophysical Chemistry 2005 MSc Molecular Biology 1978 MSc Neural Networks 1976 BSc Computers & Cybernetics
Top Papers Wilson RJ (2008) Towards a cure for dementia: the role of axonal transport in Alzheimer’s disease. Sci. Prog. 91(1), 65–80
What is the greatest void to date in our knowledge of Alzheimer's Disease? Cause/s, obviously, and relation to ageing neuron.
What are the top three papers (not yours) you have read recently? Roy S, Zhang B, Lee VM-Y, Trojanowski JQ (2005) Axonal transport defects: a common theme in neurodegenerative diseases. Acta Neuropathol. 109, 5–13
Lindvall O & Kokaia Z (2006) Stem cells for the treatment of neurological disorders. Nature 441, 1094-1096
If resources were not limited, what research projects would you pursue? Impact of viral infection on axonal transport. Finding out if/how far SENS (http://www.mfoundation.org/sens) works.
What is your leading hypothesis? I subscribe to the viral infection hypothesis. My guess is that sporadic AD is caused by collateral damage from viral infection disrupting axonal transport in turn causing neurodegeneration.
What piece of missing evidence would help prove it? Interaction of viruses with axonal transport initiating transport dysfunction.
What is your fallback position? Incidence of late-onset AD is correlated with age which points to accumulation of random damage to neurons. If so, then it is cellular ageing that we must focus on and, perhaps, SENS is the way forward.