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Researcher Profile - Jordan Tang Get Newsletter
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Home: Community: Researcher Profiles
Researcher Profile

RESEARCHER INFORMATION
First Name:Jordan
Last Name:Tang
Title:Member and Head
Advanced Degrees:Ph. D.
Affiliation:Oklahoma Medical Research Foundation
Department:Protein Studies Program
Street Address 1:825 NE 13th Street
City:Oklahoma City
State/Province:OK
Zip/Postal Code:73104
Country/Territory:U.S.A.
Phone:405-271-7291
Fax:405-271-7249
Email Address: 
Disclosure:
(view policy) 
 
View all comments by Jordan Tang
Clinical Interests:
Alzheimer Disease
Research Focus:
beta-secretase
Work Sector(s):
Research institute
Web Sites:
Personal: none
Professional: www.omrf.ouhsc.edu
Lab: www.omrf.ouhsc.edu
Researcher Bio
My laboratory is interested in the study of beta-secretase and the development of its inhibitors. The research activities includes the structure and function relationships, the biological and pathological roles, the intracellular trafficking, the cellular regulation and the inhibitor design and testing of beta-secretase.
Top Papers
● Lin, X., Koelsch, G., Wu, S., Downs, D., Dashti, A., Tang, J. (2000) Human aspartic protease memapsin 2 cleaves the β-amyloid precursor protein, Proc. Natl. Acad. Sci, USA 97, 1456-1460.
● Ghosh, A.K., Shin, D., Downs, D., Koelsch, G., Lin, X., Ermolieff, J., Tang, J. (2000) Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J. Am. Chem. Soc., 122, 3522-3523.
● Hong, L., Koelsch, G., Lin, X., Wus, S., Terzyan, S., Ghosh, A., Zhang, X.C., Tang, J. (2000) Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complex with Inhibitor. Science 290:150-153.
● Ermolieff, J., Loy, J.A., Koelsch, G., Tang, J. (2000) Proteolytic Activation of Recombinant Pro-memapsin 2 (Pro-β-Secretase) Studies with New Fluorogenic Substrates. Biochemistry 39(40):12450-12456.
● Turner, R.T., Kolesch, G., Hong, L., Castenheira, P., Ghosh, A., Tang, J. (2001)
Subsite Specificity of Memapsin 2 (β-Secretase) Implications for Inhibitor Design
Biochemistry 40, 10001-10006.
● Ghosh, A.K., Bilcer, G., Harwood, C., Kawahama, R., Shin, D., Hussain, K.A., Hong,
L., Loy, J.A., Nguyen, C., Koelsch, G., Ermolieff, J. and Tang, J. (2001) Structure-
Based Design: Potent Inhibitors of Human Brain Memapsin 2 (beta-Secretase)
J. Med. Chem. 44, 2865-2868.
● Ghosh, A., Hong, L., Tang, J. (2002) β-Secretase as a Therapeutic Target for Inhibitor
Drugs, Current Medicinal Chemistry 8, 1135-1144.
● Turner, R.T., Loy, J.A., Nguyen, C., Devasamudram, T., Ghosh, A., Koelsch, Tang, J.
(2002) Specificity of Memapsin 1 and its Implications on the Design of Memapsin
2 (β-Secretase) Inhibitor Selectivity, Biochemistry 27, 8742-8746.
● Hong, L., Turner, R.T., Koelsch, G., Ghosh, A., Tang, J. (2002) Memapsin 2
(β-Secretase) as a Therapeutic Target, Biochemical Society Transactions 30,
530-534.
● He, X., Zhu, G., Koelsch, G., Rodgers, K.K., Zhang, X.C. and Tang, J. (2003)
Biochemical and structural characterization of the interaction of memapsin 2
(beta-secretase) cytosolic domain with the VHS domain of GGA proteins.
Biochemistry 42,12174-1280.
● Hong, L. and Tang, J. (2004) Flap position of free memapsin 2 (beta-secretase), a
model for flap opening in aspartic protease catalysis.Biochemistry 43, 4689-
4695.
● Chang, W.P., Koelsch, G., Wong, S., Downs, D., Da, H., Weerasena, V., Gordon, B.,
Devasamudram, T., Bilcer, G., Ghosh, A.K. and Tang, J. (2004) In vivo
inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors. J.
Neurochem. 89,1409-1416.
What is the greatest void to date in our knowledge of Alzheimer's Disease?
The mechanism on the physiological and pathological roles of amyloid-beta.
What are the top three papers (not yours) you have read recently?
* Kamenetz et al. (2003) Neuron 37:925-37.
* Khvotchev and Sudhof (2004)J. Biol. Chem. 279: 47101-8.
*
If resources were not limited, what research projects would you pursue?
Cellular regulation of Abeta production.
What is your leading hypothesis?
Some of the regulation of Abeta production is done through the control of endocytosis of APP and beta-secretase.
What piece of missing evidence would help prove it?
Data linking endocytosis to the production of Abeta.
What is your fallback position?
The Abeta produced in the endocytic pathway is only part of the total Abeta production. The secretory pathway may be a significant source of Abeta and its regulation.

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