What is the greatest void to date in our knowledge of Alzheimer's Disease? The reason. What causes it? What initiates and promotes it? What launches the pathological cascades, and what these in fact are, and in what chronological order and order of importance. All there is to it. Could it be we're astray with amyloid and cholinergic hypotheses? The vascular component of AD is interesting.
What is your leading hypothesis? I don't know if I really have any. I try to stay open to ideas. I try to avoid getting stuck with any dogmas. The vascular angle seems interesting.