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| First Name: | Jose Joaquin | | Last Name: | Merino | | Title: | PhD | | Advanced Degrees: | Master | | Department: | Hospital Universitario ¨La Paz¨ (Madrid). IdiPaz | | Street Address 1: | c/ Paseo de la Castellana 261. | | Street Address 2: | josem2005@yahoo.es | | State/Province: | Madrid | | Zip/Postal Code: | 28046 | Country/Territory: | Spain | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 28 March 2012]
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View all comments by Jose Joaquin Merino
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Tauopathies, Aging Process, Stroke and Trauma
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Signal transduction, Apoptosis/Cell cycle, Genetics, Neuroimmunology, NeuroAIDS
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NeuroAIDS (HIV Neuropathogenesis and neuroinflammation), Research institute
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Education
1. BsCh. Complutense University UCM
(Madrid, Spain)
2. PhD. Complutense University. Biochemistry and Molecular Biology
Research
1. UNED and UCM (School of Medecine, Madrid)
2. Schollar Research. USA. Postdoctoral fellow
3. CIB (CSIC). Spanish Council Research.
4. Hospital Donostia (Neurogenetics).
Instituto Biodonostia. Basque Country.
5. Conway Institute of Molecular Biology (Ireland)
5. Hospital Universitario ¨La Paz¨(Madrid).UAM
Instituto de Investigación Sanitaria (IdiPaz)
Colaborators
1. UCLA (LA). USA
2. Harvard Medical School(USA).
3. School of Medecine. UCM (Madrid)
4. Neuroscience Lab. Oviedo University (Asturias, Spain)
5. IdiPaz. HULP. UAM (Madrid)
Teaching/Research
1. Neuroscience (Developmental Neuroscience) Molecular and Cellular Neuroscience. Neuropharmacology (Academy)
Thesis director: ¨Role of chemokines in neural plasticity and neuropathology¨
Research Network
1.CIBERNED. Neurodegenerative diseases.
2.RENEVAS. Neurovascular Research Network
Selected talks
1. Role of cell adhesion molecules in HIV-1 neuropathogenesis: interaction with chemokines.
2. PGRN promotes repair in damaged neurons: neuroprotection by CX3CL1.
3.Apoptosis mediated by chemokines CXCL12/CX3CL1 in neuropathology.
Active projects:
1. Role of Cell Adhesion Molecules in HIV-1 neuropathogenesis: interaction with chemokines.
2. Biomarkes of cognitive disfunction in HIV-1 infected patients
3. Regulation of chemokines by Cerebrolysin (Brain porcine peptide) in the ischemic brain
4. Inflammation and PGRN haploinsuficency in frontotemporal dementia.
3. Protective effects of curcumine against corticosterone and gp120 cell death in the rat brain |
1. Merino JJ, Aller MA, Rubio S, Arias N, Nava MP, Loscertales M, Arias J, Arias JL. Gut-brain chemokine changes in portal hypertensive rats.Dig Dis Sci. 2011 Aug;56(8):2309-17. Epub 2011 Feb 24 (IF: 2.1)
2. Merino JJ, Largo C, Caz V, Ibarra L, Posadas S, de Miguel E. Growth hormone (GH) increases neural cell adhesion (NCAM) polysialylation state in the dentate gyrus of gamma irradiated rats. Synapse. 2011 Apr 27. doi 10.1002/syn.20945. IF: 2.92
3.Fiala M, Avagyan H, Merino JJ, Bernas M, Valdivia J, Espinosa-Jeffrey A, Witte M, Weinand M.Chemotactic and mitogenic stimuli of neuronal apoptosis in patients with medically intractable temporal lobe epilepsy. Pathophysiology. 2012 Mar 21
4. Merino et al. Chronic stress regulates CXCR4/SDF1, CX3CR1/Fractalkine and CCR5/RANTES chemokines in the CNS: effects of chemokine blockers in memory formation. in press, IF: 4.1
5. Merino JJ, Montes ML, Blanco A, Bustos MJ, Oreja-Guevara C, Bayon C, Cuadrado A, Lubrini G, Cambron I, Munoz A, Cebolla S, Gutierrez-Fernandez M, Bernardino JI, Arribas JR, Fiala M. HIV-1 neuropathogenesis. Rev Neurol. 2011 Jan 16;52(2):101-11. IF: 1.23
6. Merino JJ, CXCR4/SDF-1α-chemokine regulates neurogenesis and/or angiogenesis within the vascular niche of ischemic rats; does SDF-1α play a role in repair? Merino JJ, Gutiérrez M, Rodríguez-Frutos B, Alvarez-Grech J, Alcalde ME, Vallejo-Cremades MT, Díez-Tejedor E.International Journal of Stroke (IJS). 2011 Oct;6(5):466-7. IF: 3.12
7. Alteration in cell cycle-related proteins in lymphoblasts from carriers of the c.709-1G>A PGRN mutation associated with FTLD-TDP dementia. Alquezar C, Esteras N, Bartolomé F, Merino JJ, Alzualde A, Munain AL, Martín-Requero A. Neurobiol Aging. 2011 Jan 11. [Epub ahead of print]. IF: 6.6
8. Functional recovery after hematic administration of allogenic mesenchymal stem cells in acute ischemic stroke in rats. Gutiérrez-Fernández M, Rodríguez-Frutos B, Alvarez-Grech J, Vallejo-Cremades MT, Expósito-Alcaide M, Merino JJ, Roda JM, Díez-Tejedor E. Neuroscience. 2011 Feb 23;175:394-405. Epub 2010 Dec 7. IF: 3.3
9. Gutiérrez M, Merino JJ, de Leciñana MA, Díez-Tejedor E. Cerebral protection, brain repair, plasticity and cell therapy in ischemic stroke. Cerebrovasc Dis. 2009;27 Suppl 1:177-86. Epub 2009 Apr 3.IF: 3.5
10. Sistiaga A, Urreta I, Jodar M, Cobo AM, Emparanza J, Otaegui D, Poza JJ, Merino JJ, Imaz H, Martí-Massó JF, López de Munain A. Cognitive/personality pattern and triplet expansion size in adult myotonic dystrophy type 1 (DM1): CTG repeats, cognition and personality in DM1. Psychol Medicine. 2010 Mar;40(3):487-95. Epub 2009 Jul 23. IF: 5.1 |
Merino J, Aller MA, Rubio S, Arias N, Nava MP, Loscertales M, Arias J, Arias JL. Gut-brain chemokine changes in portal hypertensive rats.Dig Dis Sci. 2011 Aug;56(8):2309-17. Epub 2011 Feb 24.
Department of Surgery I, School of Medicine, Complutense University of Madrid (UCM)
Plaza de Ramón y Cajal s.n, 28040, Madrid,
BACKGROUND: Hepatic encephalopathy is a syndrome whose physiopathology is poorly understood; therefore, current diagnostic tests are imperfect and modern therapy is nonspecific. Particularly, it has been suggested that inflammation plays an important role in the pathogenesis of portal hypertensive encephalopathy in the rat.
AIM: We have studied an experimental model of portal hypertension based on a triple partial portal vein ligation in the rat to verify this hypothesis.
METHODS: One month after portal hypertension we assayed in the splanchnic area (liver, small bowel and mesenteric lymph nodes) and in the central nervous system (hippocampus and cerebellum) fractalkine (CX3CL1) and stromal cell-derived factor alpha (SDF1-α) as well as their respective receptors (CX3CR1 and CXCR4) because of their key role in inflammatory processes.
RESULTS: The significant increase of fractalkine in mesenteric lymph nodes (P < 0.05) and its receptor (CX3CR1) in the small bowel (P < 0.05) and hippocampus (P < 0.01), associated with the increased expression of SDF1-α in the hippocampus (P < 0.01) and the cerebellum (P < 0.01) suggest that prehepatic portal hypertension in the rat induces important alterations in the expression of chemokines in the gut-brain axis.
CONCLUSION: The present study revealed that portal hypertension is associated with splanchnic-brain inflammatory alterations mediated by chemokines.
Chemokine blockers exert neuroprotection in the hippocampus of hypertensive rats.
Etanol promotes apoptosis in the CNS by aberrant chemokine receptor activation. |
Functional recovery after hematic administration of allogenic mesenchymal stem cells in acute ischemic stroke in rats. Gutiérrez-Fernández M, Rodríguez-Frutos B, Alvarez-Grech J, Vallejo-Cremades MT, Expósito-Alcaide M, Merino JJ, Roda JM, Díez-Tejedor E. Neuroscience. 2011 Feb 23;175:394-405. Epub 2010 Dec 7. IF: 3.3
To analyze how CXCR4/CCR5 chemokine blockadge affects neurogenesis in the CNS of ischemic rats. |
SDF1 Alpha promotes neurogenesis in the dentate gyrus of gamma irradiated rats. |
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