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| First Name: | Charles | | Last Name: | Barr | | Title: | Therapeutic Area Director | | Advanced Degrees: | MD, MPH | | Affiliation: | Roche Laboratories Inc. | | Department: | Medical Affairs | | Street Address 1: | 340 Kingsland Street | | City: | Nutley | | State/Province: | NJ | | Zip/Postal Code: | 07110 | Country/Territory: | U.S.A. | | Phone: | 973-562-3158 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports the following financial or other potential conflicts of interest: [Last Modified: 10 September 2006]
2003 to present: Employee of Roche, a pharmaceutical company developing therapies for Alzheimer disease
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Alzheimer Disease, Parkinson Disease, Aging Process, Prion Diseases
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Clinical trials, DNA microarrays, Bioinformatics/Statistics, Neuroimmunology, Genetics, Neurotransmission, Diagnosis, Epidemiology, Oxidative Stress, Drug screening
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Currently therapeutic area director at pharma company responsible for clinical trials, outcomes research and exploratory data analysis/data mining. Learning about new pipeline compounds for Alzheimers Disease. Total of 11 years experience in pharma industry.
Prior 15 years academic research, clinical practice and teaching at University of North Dakota, Harvard University, and Michigan State University.
Physician board-certified in general internal medicine (1980). MPH in Nutrition. NIH/NLM fellowship in Medical Informatics at Brigham & Women's Hospital (1985-87). Post-doctoral training at Harvard School of Public Health in biostatistics, epidemiology, meta-analysis, biomedical computing (1985-1990). Consultant to Harvard Medical School on the UMLS project.
Research interests include computerized knowledge representation and inferencing via semantic networks/webs, clinical trial registries and meta-analysis. Knowledge discovery and data mining for drug development. |
1. Siris ES, Harris ST, Rosen CJ, Barr CE, Arvesen JN, Abbott TA, Silverman S. Adherence to bisphosphonate therapy and fracture rates in osteoporotic women: relationship to vertebral and nonvertebral fractures from 2 US claims databases. Mayo Clin Proc. 2006 Aug;81(8):1013-22. PMID: 16901023
2. Ezzat S, Asa SL, Couldwell WT, Barr CE, Dodge WE, Vance ML, McCutcheon IE. The prevalence of pituitary adenomas: a systematic review.
Cancer. 2004 Aug 1;101(3):613-9. PMID: 15274075
3. Zhao SZ, Dodge WE, Spalding W, Barr CE, Li JZ. Length of hospital stay and cost of Staphylococcus and Streptococcus infections among hospitalized patients. Clin Ther. 2002 May;24(5):818-34. PMID: 12075949
4. Wang JT, Barr CE, Goldfarb SD. Impact of chest pain on cost of migraine treatment with almotriptan and sumatriptan. Headache. 2002 Jan;42 Suppl 1:38-43. PMID: 11966863
5. Venditti LN, Arcelus A, Birnbaum H, Greenberg P, Barr CE, Rowland C, Williamson T. The impact of antidepressant use on social functioning: reboxetine versus fluoxetine. Int Clin Psychopharmacol. 2000 Sep;15(5):279-89.
PMID: 10993130
6. Enderle JD, Staton RD, Gerst JW, Barr CE, Brumback RA. The electroencephalographic pattern during electroconvulsive therapy. III. Analysis of frontotemporal and nasopharyngeal spectral energy. Clin Electroencephalogr. 1986 Apr;17(2):66-77. PMID: 3731498
7. Das G, Barr CE, Carlson J. Reduction of digoxin effect during the digoxin-quinidine interaction. Clin Pharmacol Ther. 1984 Mar;35(3):317-21.
PMID: 6697639
8. Brumback RA, Barr CE. Myopathy in acromegaly. A case study. Pathol Res Pract. 1983 Jun;177(1):41-6. PMID: 6622293
9. Gerst JW, Enderie JD, Staton RD, Barr CE, Brumback RA. The electroencephalographic pattern during electroconvulsive therapy II. Preliminary analysis of spectral energy. Clin Electroencephalogr. 1982 Oct;13(4):251-6.
PMID: 7172456 |
Chong MS, Lim WS, Sahadevan S. Biomarkers in preclinical Alzheimer's disease. Curr Opin Investig Drugs. 2006 Jul;7(7):600-7. PMID: 16869111
Dominguez YL, Hernandez M, Matos CM, Zhou D.
Is B vitamins deficiency associated with prevalence of Alzheimer's disease in Cuban elderly? Nutr Health. 2006;18(2):103-18. Review.
PMID: 16859173
Nunomura A, Castellani RJ, Zhu X, Moreira PI, Perry G, Smith MA. Involvement of oxidative stress in Alzheimer disease. J Neuropathol Exp Neurol. 2006 Jul;65(7):631-41. Review. PMID: 16825950 |
Develop a large integrated database with clinical, genetic and epidemiologic data on risk factors. |
Alzheimer's is a multifactorial disease with genetic, dietary and environmental components. Individual cases may result from different combinations of factors. |
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