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| First Name: | Mervyn | | Last Name: | Monteiro | | Title: | Professor | | Advanced Degrees: | Ph.D. | | Affiliation: | University of Maryland, Baltimore | | Department: | Department of Anatomy and Neurobiology, BioMET | | Street Address 1: | Room N352 | | Street Address 2: | 725 West Lombard Street | | City: | Baltimore | | State/Province: | MD | | Zip/Postal Code: | 21201 | Country/Territory: | U.S.A. | | Phone: | 410-706-8132 | | Fax: | 410-706-8184 | | Email Address: |  |
Disclosure:
(view policy)
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View all comments by Mervyn Monteiro
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Prion Diseases, Neurodevelopmental Disorders (Down syndrome, etc.), Polyglutamine Disorders (Huntington's, etc.), Alzheimer Disease, Tauopathies, Aging Process, Parkinson Disease
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Apoptosis/Cell cycle, Signal transduction, Genetics, A-beta PP/A-beta, Molecular and Cell biology, Neurobiology, Oxidative Stress, Protein structure/chemistry, Tau/Cytoskeleton
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EDUCATION:
BSc with 1st Class Honors in Microbiology, June 1979; Queen Elizabeth College, University of London, England, U.K.
Ph.D. in Microbiology and Molecular Biology, January 1983; Nat. Ins. for Medical Res. (MRC) Mill Hill, London, Dept of Microbiology; Thesis title: Characterization of the replication terminus of the Bacillus subtilis chromosome.
Post-doctoral, January 1983 - December 1986; Nat. Ins. for Medical Res. Mill Hill London, Department of Developmental Biochemistry; Advisor: Dr. Robert Cox: Research Projects: Actin and tubulin genes of Physarum.
Post-doctoral, December 1986 - August 1989; The Johns Hopkins University, School of Medicine, Advisor: Dr. Don Cleveland; Research Project: Expression of neurofilament genes in fibroblasts and transgenic mice.
Assistant Professor Sept 1989 - June 1996.
Associate Professor July 1996 - June 2002.
Professor July 2002 -present. University of Maryland, UMBI and School of Medicine
AWARDS AND HONORS Helen R. White Prize 1979 (Queen Elizabeth College- most promising student in Microbiology); MRC postgraduate scholarship 1979 - 1983; MRC Staff (Post-doctoral fellow) 1983 - 1986. Awarded Traveling Grants from The Royal Society and the Wellcome Trust 1986; American Heart Association post-doctoral fellowship award 1987 - 1989; Certificate of Merit. Young Investigators' Day 1989 -The Johns Hopkins University.
SERVICE 1992 Site Visit Reviewer Program Project grant on ALS (NINDS); 1992 Ad Hoc Reviewer for Neurology (B-1) Study Section of National Institutes of Health; 1992 Ad Hoc Reviewer for Neurological Sciences (NLS1) Study Section of National Institutes of Health; 1995 Ad Hoc Reviewer for Neurological Sciences (ZRG1-NLS1) Study Section of NIH; 1996 Ad Hoc grant reviewer for NSF; 1996 Ad Hoc reviewer for NIH Fogarty International center grant; 1997 Ad Hoc reviewer Program Project Grant, NIA. 2001- present MDCN1 NIH Regular member; 1998, & 2000-Correspondent for The Alzheimer's Research Forum Web site (ASCB meetings and World AD congress). 2001- Alzheimer’s Association Ad Hoc reviewer.
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1. Monteiro, M.J., Hicks, C., Gu, L. and Janicki, S. (1994). Determinants for intracellular sorting of cytoplasmic and nuclear intermediate filaments. J. Cell Biol. 127:1327-1343.
2. Monteiro, M.J. and Mical, T. (1996) Resolution of kinase activities during the HeLa cell cycle: Identification of kinases with cyclic activities. Experiment Cell Research 223:443-451.
3. Starr, R., Attema, B., DeVries, G. and Monteiro, M.J. (1996) Neurofilament phosphorylation is modulated by myelination. J. Neuroscience Research 44:328-337.
4. Xiao, J., Perry, G., Troncoso, J. and Monteiro, M.J. (1996) a Calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease. J. Neuropath & Exp. Neurol. 55:954-963.
5. S. Janicki and Monteiro, M.J. (1997) Increased Apoptosis arising from Increased Expression of the Alzheimer’s Disease-associated Presenilin-2 Mutation (N141I). J. Cell Biol. 139:485-495.
6. T. Mical and Monteiro, M.J. (1998) The role of sequences unique to nuclear intermediate filaments in the targeting and assembly of human lamin B: Evidence for lack of interaction of lamin B with its putative receptor. J. Cell Science 111:3471-3485.
7. Stabler, S.M. Ostrowski, L.L. Janicki, S.M. and Monteiro, M.J. (1999) A myristoylated calcium binding protein that preferentially interacts with the Alzheimer’s Disease Presenilin 2 protein. J. Cell Biol. 145:1277-1292.
8. Janicki S.M. and Monteiro, M.J. (1999) Presenilin overexpression arrests cells in the G1 phase of the cell cycle. Arrest potentiated by the Alzheimer’s Disease PS2(N141I) mutant. Am. J. Pathol. 155:135-144.
9. Mah, A., Perry, G., Smith M.A., and Monteiro, M.J. (2000) Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation. J. Cell Biology. 151: 847-862.
10. Janicki, S.M., Stabler, S.M. and Monteiro, M.J. (2000) Familial Alzheimer’s Disease Presenilin-1 mutants potentiate cell cycle arrest. Neurobiology of Aging 21:829-836.
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The exact mechanism that leads to neurodegeneration (cell loss). |
Bence et al. Science 292:1552-1555 (2001) Impairment of the Ubiquitin-Proteasome System by Protein Aggregation.
Vassar et al. Science 286: 735-741. (1999) B-secretase cleavage of Alzheimer's Amyloid precursor protein by the transmembrane aspartic protease BACE.
Warrick et al. Nature genetics 23:425-428 (1999) Supression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.
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A systematic approach of studying genes involved in neurodegeneration in animals (mouse, C.elegans and Drosophila) and cell cultures by inactivating or misexpressing the culprit proteins and their associated proteins. |
Cell in AD die by apoptosis due to cell stress.
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Protein misfolding causes dysfunction of the Ubiquitin-proteasome system in neurodegenerative diseases. |
Culture and animals models demonstrating the exact mechanism for how cells first succumb to the death signals. |
Don't know as yet. Will wait till the cookie crumbles! |
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