|
|
|
| First Name: | Cheng-Xin | | Last Name: | Gong | | Title: | Lab head | | Advanced Degrees: | M.D., M.S. | | Affiliation: | New York State Institute for Basic Research | | Department: | Neurochemistry | | Street Address 1: | 1050 Forest Hill Road | | City: | Staten Island | | State/Province: | NY | | Zip/Postal Code: | 10314 | Country/Territory: | U.S.A. | | Phone: | 718-494-5248 | | Fax: | 718-494-1080 | | Email Address: |  |
Disclosure:
(view policy)
|
Member reports no financial or other potential conflicts of interest. [Last Modified: 16 September 2005]
|
|
|
View all comments by Cheng-Xin Gong
|
Aging Process, Tauopathies, Alzheimer Disease
|
Neurobiology, Neuropathology, Molecular and Cell biology, Tau/Cytoskeleton, Signal transduction, Protein structure/chemistry, Proteomics
|
Gong, C.-X., Shaikh, S., Wang, J.-Z., Zaidi, T., Grundke-Iqbal, I., and Iqbal, K. Protein phosphatase activity towards abnormally phosphorylated tau: decrease in Alzheimer disease brain. J. Neurochem. 1995; 65:732-738
Gong, C.-X., Lidsky, T., Wegiel, J., Wisniewski, H.M., Grandke-Iqbal, I., and Iqbal, K. Phosphorylation of Microtubule-associated Protein Tau Is Regulated by Protein Phosphatase 2A: Implication for Neurofibrillary Degeneration in Alzheimer Disease. J Biol Chem 2000; 275(8):5535-5544.
Gong, C.-X., Liu, F., Wu, G., Rossie, S., Wegiel, J., Li, L., Grundke-Iqbal, I., and Iqbal, K. Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5. J. Neurochem. 2004; 88:298-310.
Liu, F., Iqbal, K., Grundke-Iqbal, I., Hart, G.W., and Gong, C.-X. O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease. Proc Natl Acad Sci USA. 2004; 101:10804-10809.
Tian Q, Lin ZQ, Wang XC, Chen J, Wang Q, Gong C-X, Wang JZ. Injection of okadaic acid into the meynert nucleus basalis of rat brain induces decreased acetylcholine level and spatial memory deficit. Neuroscience. 2004; 126(2):277-284.
Liu, SJ, Zhang, JY, Li, HL, Fang, ZY, Wang Q, Deng, HM, Gong, CX, Grundke-Iqbal, I, Iqbal, K, Wang, JZ. Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. J. Biol. Chem. 2004; 279:50078-50088.
Huang, Y., Tanimukai, H., Liu, F., Iqbal, K., Grandke-Iqbal, I., and Gong, C.-X. Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain. Eur. J. Neurosci. 2004; 20:3489-3497. (This paper was highlighted by Nature Review Neuroscience 2005; 6:94)
Liu, F., Iqbal, K., Grundke-Iqbal, I., Rossie, S., Gong, C.-X. Dephosphorylation of tau by protein phosphatase 5: Impairment in Alzheimer disease. J. Biol. Chem. 2005; 280:1790-1796.
Gong, C.-X., Liu F., Grundke-Iqbal, I., Iqbal, K. Post-translational modifications of tau protein in Alzheimer’s disease. J. Neural Transm. 2005; 112:813-838.
Liu F, Grundke-Iqbal I, Iqbal K, Oda Y, Tomizawa K, Gong CX. Truncation and activation of calcineurin A by calpain l in Alzheimer disease brain. J Biol Chem. 2005 Sep 2; [Epub ahead of print] PMID: 16150694 [PubMed - as supplied by publisher]
|
Lack of real animal model |
|
|
Home
