|
|
|
| First Name: | Claudio | | Last Name: | Soto | | Title: | Professor and Center Director | | Advanced Degrees: | PhD | | Affiliation: | University of Texas Medical School at Houston | | Department: | Neurology | | Street Address 1: | 6431 Fannin St | | City: | Houston | | State/Province: | TX | | Zip/Postal Code: | 77030 | Country/Territory: | U.S.A. | | Phone: | 713-5007086 | | Fax: | 713-5000667 | | Email Address: |  |
Disclosure:
(view policy)
|
Member reports the following financial or other potential conflicts of interest: [Last Modified: 6 May 2009]
I am Founder, Vice-President and Chief Scientific Officer of Amprion Inc, a company focusing on development sensitive biochemical diagnosis for neurodegenerative diseases
|
|
|
View all comments by Claudio Soto
|
Alzheimer Disease, Prion Diseases
|
Animal Models, Apoptosis/Cell cycle, A-beta PP/A-beta, Neurobiology, Protein structure/chemistry, Molecular and Cell biology, Clinical trials, Neuropathology, Diagnosis, Drug screening
|
1. Castilla, J., Gonzalez, D., Saa, P., Morales, R., De Castro, J. and Soto, C. (2008) Crossing the species barrier by PrPSc replication in vitro generates new infectious prions. Cell 134: 757-768.
2. Castilla, J., Morales, R., Saa, P., Barria, M., Gambetti, P. and Soto, C. (2008) Propagation of prion strains in vitro. EMBO J. 27: 2557-2566.
3. Saa, P., Castilla, J. and Soto, C. (2006) Pre-symptomatic detection of prions in blood. Science 313: 92-94.
4. Soto, C., Estrada, L.D. and Castilla, J. (2006) Amyloid, Prions and the inherent infectious nature of misfolded protein aggregates. Trends Biochem. Sci. 31: 150-155.
5. Castilla, J., Saa, P., Hetz, C. and Soto, C. (2005) In vitro generation of infectious scrapie prions. Cell 121: 195-206.
6. Soto, C. (2003) Unfolding the role of Protein Misfolding in Neurodegenerative Diseases. Nature Rev. Neurosci. 4: 49-60.
7. Hetz, C., Russelakis, M., Maundrell, K., Castilla, J. and Soto, C. (2003) Neuronal apoptosis induced by pathological prion protein is mediated by caspase-12 and endoplasmic reticulum stress. EMBO J. 22: 5436-5445.
8. Permanne, B., Adessi, C., Saborio, G.P., Fraga, S., Frossard, M.J., Van Dorpe, J., Dewachter, I., Banks, W.A., Van Leuven, F. And Soto, C. (2002) Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a ß-sheet breaker peptide. FASEB J. 16: 860-862 (full-version published online on April 10, 2002 as 10.1096/fj.01-0841fje).
9. Saborio, G.P., Permanne, B. and Soto, C. (2001) Cyclic amplification of protein misfolding: A novel approach for sensitive detection of pathological prion protein. Nature 411: 810-813.
10. Soto, C., Sigursson, E., Morelli, L., Kumar, R.A., Castaño, E.M. and Frangione, B. (1998) ß-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy. Nature med. 4: 822-826.
|
|
|
Home
