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| First Name: | John | | Last Name: | Schenck | | Title: | Senior Scientist | | Advanced Degrees: | MD, Phd | | Affiliation: | General Electric Global Research | | Department: | Magnetic Resonance Imaging | | Street Address 1: | 1 Research Circle | | City: | Schenectady | | State/Province: | NY | | Zip/Postal Code: | 12309 | Country/Territory: | U.S.A. | | Phone: | (518) 387-6543 | | Fax: | (518) 387-6923 | | Email Address: |  |
Disclosure:
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Member reports no financial or other potential conflicts of interest. [Last Modified: 14 March 2006]
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View all comments by John Schenck
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Aging Process, Neuromuscular Disorders (ALS, etc.), Alzheimer Disease, Polyglutamine Disorders (Huntington's, etc.), Tauopathies, Parkinson Disease
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Brain imaging, Oxidative Stress
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PhD in Solid State Physics, RPI, 1965. MD from Albany Medical College (AMC), 1977. Affiliated with GE Research Labs 1965-present. Associate Professor Syracuse University Electrical Engineering 1969-1973. Department of Emergency Medicine, Ellis Hospital Schenecady NY 1979-1989. Adjunct Professor of Neurology at AMC, 2003. Early involvement with MRI at GE beginning in 1978. Participated in development of MRI technology - high field superconducting systems (1.5 and 4 tesla), gradient coils and RF coils (surface coils and birdcage coils) and MR safety issues. Research in high-field MR imaging of brain iron deposition. Since 2002 collaborating with Dr. Earl Zimmerman of AMC on brain iron deposition as possible pathogenic agent and biomarker in Alzheimer and related diseases. |
Schenck, Physical interactions of static magnetic fields with living tissues, Prog Biophys Mol Biol 87, 105-204 (2005)
Schenck, Zimmerman, High-field magnetic resonance imaging of brain iron: birth of a biomarker? NMR Biomed 17, 433-445 (2004)
Schenck, Magnetic resonance imaging of brain iron, J Neurol Sci 207, 99-102. (2003)
Schenck, Safety of strong, static magnetic fields, JMRI 12, 2-19 (2000)
Schenck, The role of magnetic susceptibility in magnetic resonance imaging: magnetic field compatibility of the first and second kinds, Med Phys 23, 815-850 (1996)
Schenck, Imaging of brain iron by magnetic resonance imaging: T2 relaxation at different field strengths,J Neurol Sci 134S, 10-18 (1995)
Schenck, Jolesz, Roemer, et al., Superconducting open-configuration MR imaging system for image-guided therapy, Radiology 195, 805-814 (1995)
Schenck, Dumoulin, Redington, et al., Human exposure to 4.0-tesla magnetic fields in a whole-body scanner, Med Phys 19, 1089-1098 (1992)
Schenck, Hart, Foster, et al., High Resolution magnetic resonance imaging using surface coils, Magnetic Resonance Annual, HY Kressel (ed.) (Raven Press, New York, 1986), pp. 123-160. |
In my area of interest, iron dysmetabolism and it relation to neurodegeneration, I think the lack of a confirmed and comprehensive understanding of the dynamics of brain iron metabolism and the details of its relation to oxidative stress are the largest voids. This would include details of iron influx, efflux and storage in the brain and the relation of the labile iron pool to the storage pools. This would give insight into the issue of whether iron accumulation is truly a measure of tissue injury or an epiphenomenon. |
Falangola MF, Lee SP, Nixon RA et al. Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice. Neurochem Res. 2005 Feb;30(2):201-5
Zhang P, Land W, Lee S et al. Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism. J Struct Biol. 2005 May;150(2):144-53.
Haacke EM, Cheng NY, House MJ, et al. Imaging iron stores in the brain using magnetic resonance imaging. Magn Reson Imaging. 2005 Jan;23(1):1-25. Review |
I would like to see a systematic study of brain iron metabolism and storage as a function of age and the progression of various disease states. This would include medical imaging (predominantly MRI) as well as neuropathology using electron microscopy, X-ray microanalysis, neurochemistry, etc. It woould be great if the classic autopsy studies of Hallgren and Sourander could be repeated using modern technology. This would provide reliable baseline data to inform the interpretation and utilization of non-invasive MR imaging in characterizing disease progression and response to therapy. |
High field MRI can provide a meaningful, non-invasive technique for monitoring the progression and response to therapy of Alzheimer's disease and several other neurodegenerative disorders. |
Tissue-level understanding of relation between storage iron concentration (which can be studied by MRI) and the surmised tissue injuring processes taking place at the level of the labile iron pool. |
Further development of alternative neuroimaging techniques such as volumetric MRI (to characterize atrophy), fMRI and PET. |
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