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| First Name: | Luc | | Last Name: | Buee | | Title: | Research Director | | Advanced Degrees: | Ph.D. | | Affiliation: | CNRS | | Department: | INSERM U837 Alzheimer & Tauopathies | | Street Address 1: | Inst. Medecine Predictive & Recherche Therapeutique | | Street Address 2: | Place de Verdun | | City: | LILLE | | State/Province: | cedex | | Zip/Postal Code: | F-59045 | Country/Territory: | France | | Phone: | 33 320 298866 | | Fax: | 33 320 622079 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 6 October 2009]
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View all comments by Luc Buee
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Parkinson Disease, Polyglutamine Disorders (Huntington's, etc.), Tauopathies, Aging Process, Neuromuscular Disorders (ALS, etc.), Alzheimer Disease
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Microscopy, Apoptosis/Cell cycle, Drug screening, Brain imaging, Signal transduction, Neuropathology, A-beta PP/A-beta, Neuroimmunology, Clinical trials, Diagnosis, Protein structure/chemistry, Molecular and Cell biology, Chemistry/Pharmacology, Neurotransmission, Electrophysiology, Animal Models, Neurobiology, Oxidative Stress, Proteomics, Tau/Cytoskeleton, Genetics
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Since 2007, Head of the Inserm team "Alzheimer & Tauopathies", Inserm U837, Lille, France
Jan-Dec 2006, Head of Inserm laboratory U815
Since October 2001, Research Director at the French National Center for Scientific Research (Directeur de Recherche 2ème classe CNRS), INSERM U422, Lille, France.
Oct 1998-Sept 2001: Research associate (Chargé de Recherche 1ère classe CNRS) INSERM U422.
Oct 1994-Sept 1998: Research assistant (Chargé de Recherche 2ème classe CNRS) INSERM U422.
Oct 1992-Sept 1994: France Alzheimer Postdoctoral fellow, INSERM U156, Lille, France.
Juil 1988-Oct 1992: PhD student, The Mount Sinai Medical Center, Department of Geriatrics, Laboratory of NeuroImmunology, New York, NY, USA, collaboration between Pr. Howard Fillit and Dr. André Delacourte (INSERM, Lille, France).
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1. Lambert JC, Schraen-Maschke S, Richard F, Fievet N, Rouaud O, Berr C, Dartigues JF, Tzourio C, Alpérovitch A, Buée L, Amouyel P. Association of plasma amyloid beta with risk of dementia: the prospective Three-City Study. Neurology. 2009 Sep 15;73(11):847-53. PubMed PMID: 19752451.
2. Belarbi K, Schindowski K, Burnouf S, Caillierez R, Grosjean ME, Demeyer D,Hamdane M, Sergeant N, Blum D, Buée L. Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease. Curr Alzheimer Res. 2009 Apr;6(2):152-7. PubMed PMID: 19355850.
3. Dhaenens CM, Schraen-Maschke S, Tran H, Vingtdeux V, Ghanem D, Leroy O, Delplanque J, Vanbrussel E, Delacourte A, Vermersch P, Maurage CA, Gruffat H, Sergeant A, Mahadevan MS, Ishiura S, Buée L, Cooper TA, Caillet-Boudin ML, Charlet-Berguerand N, Sablonnière B, Sergeant N. Overexpression of MBNL1 fetal isoforms and modified splicing of Tau in the DM1 brain: two individual consequences of CUG trinucleotide repeats. Exp Neurol. 2008 Apr;210(2):467-78. Epub 2007 Dec 4. PubMed PMID: 18177861.
4. Vingtdeux V, Hamdane M, Loyens A, Gelé P, Drobeck H, Bégard S, Galas MC, Delacourte A, Beauvillain JC, Buée L, Sergeant N. Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies. J Biol Chem. 2007 Jun 22;282(25):18197-205. Epub 2007 Apr 27. PubMed PMID: 17468104.
5. Schindowski K, Bretteville A, Leroy K, Bégard S, Brion JP, Hamdane M, Buée L. Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. Am J Pathol. 2006 Aug;169(2):599-616. PubMed PMID: 16877359; PubMed Central PMCID: PMC1698785.
6. Leroy O, Dhaenens CM, Schraen-Maschke S, Belarbi K, Delacourte A, Andreadis A, Sablonnière B, Buée L, Sergeant N, Caillet-Boudin ML. ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I. J Neurosci Res. 2006 Sep;84(4):852-9. PubMed PMID: 16862542.
7. Hamdane M, Dourlen P, Bretteville A, Sambo AV, Ferreira S, Ando K, Kerdraon O, Bégard S, Geay L, Lippens G, Sergeant N, Delacourte A, Maurage CA, Galas MC, Buée L. Pin1 allows for differential Tau dephosphorylation in neuronal cells. Mol Cell Neurosci. 2006 May-Jun;32(1-2):155-60. Epub 2006 May 11. PubMed PMID: 16697218.
8. Hamdane M, Bretteville A, Sambo AV, Schindowski K, Bégard S, Delacourte A, Bertrand P, Buée L. p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death. J Cell Sci. 2005 Mar 15;118(Pt 6):1291-8. Epub 2005 Mar 1. PubMed PMID: 15741232.
9. Hamdane M, Sambo AV, Delobel P, Bégard S, Violleau A, Delacourte A, Bertrand P, Benavides J, Buée L. Mitotic-like tau phosphorylation by p25-Cdk5 kinase complex. J Biol Chem. 2003 Sep 5;278(36):34026-34. Epub 2003 Jun 24. PubMed PMID: 12826674.
10. Buée L, Bussière T, Buée-Scherrer V, Delacourte A, Hof PR. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev. 2000 Aug;33(1):95-130. Review. PubMed PMID: 10967355.
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The link between amyloid and tau pathology |
Asuni AA, Boutajangout A, Quartermain D, Sigurdsson EM. Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. J Neurosci. 2007 Aug 22;27(34):9115-29. PubMed PMID: 17715348.
Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, Jucker M, Goedert M, Tolnay M. Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol. 2009 Jul;11(7):909-13. Epub 2009 Jun 7. PubMed PMID: 19503072; PubMed Central PMCID: PMC2726961
Frost B, Jacks RL, Diamond MI. Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem. 2009 May 8;284(19):12845-52. Epub 2009 Mar 11. PubMed PMID: 19282288; PubMed Central PMCID: PMC2676015.
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APP dysfunction leading to amyloid formation occurs when Tau pathology is starting: there is a real sequence of events that needs to be solved. |
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