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| First Name: | Jason | | Last Name: | Eriksen | | Title: | Assistant Professor | | Advanced Degrees: | Ph.D. | | Affiliation: | University of Houston | | Department: | Pharmacy | | Street Address 1: | 557A S&R2 | | Street Address 2: | 4800 Calhoun | | City: | Houston | | State/Province: | TX | | Zip/Postal Code: | 77006 | Country/Territory: | U.S.A. | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 29 June 2008]
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View all comments by Jason Eriksen
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Alzheimer Disease, Neurodevelopmental Disorders (Down syndrome, etc.), Tauopathies, Parkinson Disease, Aging Process
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Bioinformatics/Statistics, Tau/Cytoskeleton, Microscopy, Molecular and Cell biology, Neurobiology, A-beta PP/A-beta, Animal Models, Neuropathology, Drug screening
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I received my Ph.D. in neuroscience, studying the effects of prenatal ethanol exposure on the developing brain. From 2000-2003, I worked as a postdoctoral fellow on the relationship between anti-inflammatory compounds and AB42 (APP) in cell culture systems and transgenic models in the laboratory of Dr. Todd Golde. From 2003 to the present day, my projects have examined the role of MAPT and PGRN in various dementias. I am actively interested in the development of therapeutic treatments for neurodegenerative diseases. |
Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, Snowden J, Adamson J, Sadovnick AD, Rollinson S, Cannon A, Dwosh E, Neary D, Melquist S, Richardson A, Dickson D, Berger Z, Eriksen J, Robinson T, Zehr C, Dickey CA, Crook R, McGowan E, Mann D, Boeve B, Feldman H, Hutton M. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature. 2006 Aug 24;442(7105): 916-9. Epub 2006 Jul 16. PMID: 16862116.
Le Corre S, Klafki HW, Plesnila N, Hubinger G, Obermeier A, Sahagun H, Monse B, Seneci P, Lewis J, Eriksen J, Zehr C, Yue M, McGowan E, Dickson DW, Hutton M, Roder HM. An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice. Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9673-8. Epub 2006 Jun 12. PMID: 16769887.
McGowan E, Pickford F, Kim J, Onstead L, Eriksen J, Yu C, Skipper L, Murphy MP, Beard J, Das P, Jansen K, Delucia M, Lin WL, Dolios G, Wang R, Eckman CB, Dickson DW, Hutton M, Hardy J, Golde T. Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron. 2005 Jul 21;47(2):191-9. PMID: 16039562
Kukar T*, Murphy MP*, Eriksen JL*, Sagi SA*, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, Fauq A, Koo EH, Golde TE.Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nat Med. 2005 May;11(5):545-50. Epub 2005 Apr 17.
PMID: 15834426. *Co-first author.
Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC, Ozols VV, Jessing KW, Zavitz KH, Koo EH, Golde TE.NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest. 2003 Aug;112(3): 440-9. PMID: 12897211.
Weggen S*, Eriksen JL*, Sagi SA, Pietrzik CU, Ozols V, Fauq A, Golde TE, Koo EH. Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. J Biol Chem. 2003 Aug 22;278(34):31831-7. Epub 2003 Jun 12. PMID: 12805356. *Co-first author.
Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. J Biol Chem. 2003 Aug 15;278(33):30748-54. Epub 2003 May 31. PMID: 12777371.
Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.
Nature. 2001 Nov 8;414(6860):212-6. PMID: 11700559. |
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