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| First Name: | David | | Last Name: | Sinclair | | Title: | Professor | | Advanced Degrees: | Ph.D. | | Affiliation: | Harvard Medical School | | Department: | Pathology | Country/Territory: | U.S.A. | | Email Address: |  |
Disclosure:
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Member reports the following financial or other potential conflicts of interest: [Last Modified: 11 November 2008]
I consult for Sirtris, a GSK company.
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View all comments by David Sinclair
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Molecular and Cell biology, Animal Models
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David A. Sinclair
BIOSKETCH
(2008)
David Sinclair, Ph.D. is an Associate Professor of Pathology and Co-Director of the Glenn Laboratories for Aging Research at Harvard Medical School. He worked as a postdoctoral researcher at M.I.T. with Lenny Guarente where he discovered a cause of aging for yeast and genes that control the aging process. He was recruited to Harvard Medical School in 1999 and has published over 60 papers on the molecular biology of aging. In 2004 he co-founded Sirtris Pharmaceuticals with Dr. Christoph Westphal to develop drugs to treat age-associated diseases. In 2008, Sirtris was acquired by GSK and he remains chair of the advisory board. Dr. Sinclair has received awards including The Australian Commonwealth Prize, a Helen Hay Whitney Postdoctoral Award, a Leukemia Society Fellowship, a Ludwig Scholarship, a Harvard-Armenise Fellowship, an American Association for Aging Research Fellowship, and a Fellowship and Senior Scholarship from the Ellison Medical Foundation.
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25. Howitz, KT., Bitterman, KJ., Cohen, HY., Lamming, DW., Lavu, S., Wood, JG., Zipkin, RE., Chung P., Kisielewski, A., Zhang, L., Scherer, B., Sinclair DA. (2003) Small molecule sirtuin activators that extend S. cerevisiae lifespan. Nature, 425:191-196
27. Anderson, RA., Latorre-Esteves, M., Neves, A., Lavu, S., Taylor, C., Howitz, KT., Santos, H., Sinclair, DA. (2003). Lifespan extension by calorie restriction is independent of NAD fluctuation. Science, 302:2124-2126.
31. Cohen, HY, Miller, C, Bitterman, KJ, Wall, NR, Hekking, B, Kessler, B, Howitz, KT, Gorospe, M, de Cabo, R Sinclair, DA. (2004) Calorie restriction promotes cell survival by inducing SIRT1. Science, 305(5682):390-2
32. Wood, J, Rogina, B, Lavu, S, Howitz, KT, Helfand, SL, Tatar, M, Sinclair, DA. (2004). Sirtuin activators mimic calorie restriction and delay aging in metazoans. Nature, 430(7000):686-9.
36. Lamming, D, Latorre-Esteves, M, Medvedik, O, Wong, S.N., Tsang, F.A, Wang, C, Lin, S-J, Sinclair, DA (2005) HST2 mediates SIR2-independent lifespan extension by calorie restriction. Science, 309(5742):1861-4
40. Lamming, D, Latorre-Esteves, M, Medvedik, O, Wong, S.N., Tsang, F.A, Wang, C, Lin, S-J, Sinclair, DA (2006) HST2 mediates SIR2-independent lifespan extension by calorie restriction. Tech. Comm. Science, 312(5778):131-134
43. Baur, J, Pearson, K, et al. (25 authors), deCabo, R, Sinclair, DA. (2006) Resveratrol increases health and survival of mice on a high calorie diet. Nature 444(16): 337-342
50. Kim, D, Nguyen, MD, Fischer, A, Sananbenesi, F, Dellale I, Sui, G, Baur, J, Armour, SM, Puigserver, P., Sinclair, DA, Tsai, L-H. (2007). SIRT1 deacetylase protects against age-dependent neurodegeneration. EMBO J, 6(13):3169-3179.
54. Yang, HY, Yang, T, Baur, JA, Perez, E, Matsui, T, Carmona, JJ, Lamming, DW, Souza-Pinto, NC, Bohr, VA, Rosenzweig, A, de Cabo, R, Sauve, AA, Sinclair, DA. (2007) Nutrient-regulated NAD+ levels in mitochondria dictate cell survival. Cell, 130(6):1095-107.
56. Milne, J - 21 authors - Sinclair, Olefsky, J., D.A., Jirousek, M, Westphal, C. (2007) Novel Small Molecule Activators of SIRT1 as Therapeutics for Treatment of Type 2 Diabetes. Nature, 450(7170):712-6
58. Howitz, KT and Sinclair, DA. Xenohormesis - sensing the chemical cues of other species. (2008) Cell, 133(3):387-391
59. Pearson, K*, Baur, J*, Lewis, KN, Peshkin, L, Price, NL et al. Navas, P., Ingram, D., Wolf, N., Ungvari, Z, Sinclair, DA*, de Cabo, RA* (2008). Resveratrol delays age-related deterioration and mimics aspects of dietary restriction in mice on a standard diet. Cell Metabolism, Aug;8(2):157-68
60. Oberdoerffer, P., Michan, S. McVay, M. - 8 authors - Mills, K., Bonni, A., Yankner, B., Scully, R., Prolla, TA., Alt, FW. and David A. Sinclair, D. DNA damage-induced alterations in chromatin contribute to genomic integrity and age-related changes in gene expression. Cell, Nov 2008
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Genes that evolved to promote survival (longevity genes) can be used to treat diseases |
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