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| First Name: | Torik | | Last Name: | Ayoubi | | Title: | Dr. | | Advanced Degrees: | PhD | | Affiliation: | KU Leuven | | Department: | Center for Human Genetics | | Street Address 1: | O&N1 Herestraat 49 box 602 | | City: | Leuven | | Zip/Postal Code: | 3000 | Country/Territory: | Belgium | | Phone: | 0032-16330581 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 22 February 2011]
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Alzheimer Disease, Neurodevelopmental Disorders (Down syndrome, etc.), Tauopathies, Neuromuscular Disorders (ALS, etc.), Polyglutamine Disorders (Huntington's, etc.), Aging Process, Parkinson Disease
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A-beta PP/A-beta, Microscopy, Neurobiology, Diagnosis, DNA microarrays, Proteomics, Tau/Cytoskeleton, Stem cells, Molecular and Cell biology, Oxidative Stress, Genetics, Neuroimmunology, Neuropathology, Bioinformatics/Statistics
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My expertise centers around Genomics Research. In particular, the study of genome dynamics by analyzing the transcriptome of cells and tissues using DNA Gene Expression Microarrays and Next Generation Sequencing technologies. |
Functional annotation of heart enriched mitochondrial genes GBAS and CHCHD10 through guilt by association.
Martherus RS, Sluiter W, Timmer ED, VanHerle SJ, Smeets HJ, Ayoubi TA.
Biochem Biophys Res Commun. 2010 Nov 12;402(2):203-8. Epub 2010 Oct 1.
PMID:20888800
The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels.
Meex SJ, Weissglas-Volkov D, van der Kallen CJ, Thuerauf DJ, van Greevenbroek MM, Schalkwijk CG, Stehouwer CD, Feskens EJ, Heldens L, Ayoubi TA, Hofker MH, Wouters BG, Vlietinck R, Sinsheimer JS, Taskinen MR, Kuusisto J, Laakso M, de Bruin TW, Pajukanta P, Glembotski CC.
Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1322-7. Epub 2009 Aug 10.
PMID:19667116
Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians.
Meex SJ, van Greevenbroek MM, Ayoubi TA, Vlietinck R, van Vliet-Ostaptchouk JV, Hofker MH, Vermeulen VM, Schalkwijk CG, Feskens EJ, Boer JM, Stehouwer CD, van der Kallen CJ, de Bruin TW.
J Clin Endocrinol Metab. 2007 Jul;92(7):2720-5. Epub 2007 Apr 17.
PMID:17440018
Regulation of HMGIC expression: an architectural transcription factor involved in growth control and development.
Ayoubi TA, Jansen E, Meulemans SM, Van de Ven WJ.
Oncogene. 1999 Sep 9;18(36):5076-87.
PMID:10490844
Cell type-specific protein-DNA interactions at the cAMP response elements of the prohormone convertase 1 promoter. Evidence for additional transactivators distinct from CREB/ATF family members.
Jansen E, Ayoubi TA, Meulemans SM, Van de Ven WJ.
J Biol Chem. 1997 Jan 24;272(4):2500-8.
PMID:8999965
Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons.
Roebroek AJ, Ayoubi TA, Van de Velde HJ, Schoenmakers EF, Pauli IG, Van de Ven WJ.
Genomics. 1996 Mar 1;32(2):191-9.
PMID:8833145
Regulation of gene expression by alternative promoters.
Ayoubi TA, Van De Ven WJ.
FASEB J. 1996 Mar;10(4):453-60. Review.
PMID:8647344
Expression of the dibasic proprotein processing enzyme furin is directed by multiple promoters.
Ayoubi TA, Creemers JW, Roebroek AJ, Van de Ven WJ.
J Biol Chem. 1994 Mar 25;269(12):9298-303.
PMID:8132667
Transcriptional and posttranscriptional regulation of the proopiomelanocortin gene in the pars intermedia of the pituitary gland of Xenopus laevis.
Ayoubi TA, Jenks BG, Roubos EW, Martens GJ.
Endocrinology. 1992 Jun;130(6):3560-6.
PMID:1597153
The neuroendocrine polypeptide 7B2 is a precursor protein.
Ayoubi TA, van Duijnhoven HL, van de Ven WJ, Jenks BG, Roubos EW, Martens GJ.
J Biol Chem. 1990 Sep 15;265(26):15644-7.
PMID:2394742 |
Why the late onset (aging required) |
First gene expression changes in blood that indicate that a patient will develop a neurodegenerative disorder. |
The pathology in the brain will be "communicated" to immune cells in bonemarrow, which will respond to the disease process. |
Deatailed gene expression analysis of fractionated blood cells in order to identify the small fraction of responding cells on their way to the "injured" brain. |
No fallback required. Neurodegenerated brains are inriched in immune cells and they hav to get there from the bonemarrow. If recourced were unlimited I will identify them on their way to the brain.
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