|
|
|
| First Name: | Jun | | Last Name: | Tan | | Title: | Associate Professor | | Advanced Degrees: | Ph.D., M.D. | | Affiliation: | University of South Florida | | Department: | Psychiatry | | Street Address 1: | 3515 E Fletcher Ave | | City: | Tampa | | State/Province: | FL | | Zip/Postal Code: | 33613 | Country/Territory: | U.S.A. | | Phone: | 813-974-9326 | | Fax: | 813-974-1130 | | Email Address: |  |
Disclosure:
(view policy)
|
Member reports no financial or other potential conflicts of interest. [Last Modified: 4 February 2007]
|
|
|
View all comments by Jun Tan
|
Neurodevelopmental Disorders (Down syndrome, etc.), Aging Process, Alzheimer Disease
|
Signal transduction, Neuroimmunology, Drug screening, Molecular and Cell biology, Stem cells
|
In 1983, Dr. Jun Tan received his Bachelors of Medicine at the Third Medical University in Chongqing, China. He earned his Master degree of Science in human genetics at Fudan University, Shanghai in 1989. Three years later, he completed his Doctoral degree at the Third Medical University/Fudan University. He was then Chief of the Department of Molecular Genetics from 1990 to 1994 at the Third Medical University in Chongqing, China. He performed postdoctoral studies in 1996 at the Department of Human Genetics/Immunology at the University of Michigan, Ann Arbor. Dr Tan then completed his research fellowship in 1998 at H. Lee Moffitt Cancer & Research Institute in Tampa, Florida. After completing his research fellowship, he became Assistant Professor in Psychiatry and Microbiology & Immunology at the University of South Florida (USF) in 1998 and Associate Professor 2004. He is the Director of the Neuroimmunology in the since 2003. Dr. Tan has published over 60 scientific papers, several of them in journals such as Science, Nature Neuroscience, EMBO J, PNAS, Journal of Neuroscience, Journal of Immunology, JBC and European Journal of Immunology. |
1. Nikolic V, Bai Y, Obregon D, Hou H, Mori T, Zeng J, Ehrhart J, Shytle D, Giunta B, Morgan D, Town T, Tan J*. Transcutaneous beta-amyloid immunization of transgenic Alzheimer’s mice reduces cerebral beta-amyloid deposits without T-cell infiltration and microhemorrhage. Proceedings of the National Academy of Sciences, USA 2007 Jan 30; [Epub ahead of print].
2. Obregon D, Rezai-Zadeh K, Bai Y, Sun N, Hou H, Ehrhart J. Zeng J, Mori T, Arendash G, Shytle RD, Town T and Tan J*. ADAM10 activation is required for green tea EGCG-induced beta-secretase cleavage of amyloid precursor protein. Journal of Biological Chemistry 281 (24):16419-16427 (2006).
3. Rezai-Zadeh K, Shytle RD, Sun N, Mori T, Hou H, Jeanniton D, Ehrhart J, Townsend T, Zeng J, Hardy J, Town T and Tan J*. Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer’s transgenic mice. The Journal of Neuroscience 25 (38):8807-8814 (2005).
4. Townsend K, Town T, Lue LF, San N, Zeng J, Shytle D, Sanberg P, Fernandez F, Morgan D and Tan J*. Regulation of the Abeta-induced innate and adaptive immune responses by CD40 signaling in microglial cells. European Journal of Immunology 35 (3):901-910 (2005).
5. Shytle D, Mori T, Vendrame M, Sun N, Zeng J, Ehrhart J, Silver A, Sanberg P and Tan J*. Cholinergic modulation of microglial activation by α7 nicotinic receptors. Journal of Neurochemistry 89:337-343 (2004).
6. Mott R, Ait-Ghezala G, Town T, Mori T, Vendrame M, Zeng J, Ehrhart J, Mullan M and Tan J*. Neuronal expression of CD22: a novel mechanism for inhibiting micorglial proinflammatory cytokine production. GLIA 46:369-379 (2004).
7. Tan J, Town T, Crawford F, Mori T, DelleDonne A, Crescentini R, Obregon D, Flavell RA and Mullan MJ. Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. NATURE Neuroscience 5(12):1288-1293 (2002).
8. Tan J*, Town T, Mori T, Wu Y, DelleDonne A, Obregon D, Rojiani A, Flavell R, Mullan M. CD40 is expressed and functional on neuronal cells. EMBO J 21 (4):37224-37231 (2002).
9. Tan J*, Town T, Mori T, Wu Y, Saxe M, Crawford F, Mullan M. CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 MAPK. The Journal of Neuroscience 20 (20):7587-7594 (2000).
10. Tan J, Town T, Paris D, Mori T, Crawford F, Mattson M, Flavell R, Mullan M. The CD40-CD40L interaction leads to microglial activation after beta-amyloid stimulation. SCIENCE 286 (17):2352-2355 (1999).
|
|
|
Home
