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| First Name: | Malcolm | | Last Name: | Leissring | | Title: | Assistant Professor | | Advanced Degrees: | Ph.D. | | Affiliation: | Mayo Clinic, Jacksonville | | Street Address 1: | 4500 San Pablo Road | | Street Address 2: | Birdsall Building | | City: | Jupiter | | State/Province: | FL | | Zip/Postal Code: | 32224 | Country/Territory: | U.S.A. | | Phone: | 561-351-6769 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 19 November 2007]
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View all comments by Malcolm Leissring
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Aging Process, Alzheimer Disease, Tauopathies, Polyglutamine Disorders (Huntington's, etc.), Prion Diseases, Parkinson Disease
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A-beta PP/A-beta, medicinal chemistry, Neurobiology, Neuropathology, Oxidative Stress, DNA microarrays, Drug screening, Tau/Cytoskeleton, Molecular and Cell biology, Bioinformatics/Statistics, Chemistry/Pharmacology, Protein structure/chemistry, Proteomics, Signal transduction, Genetics, Animal Models
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1: Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe
DJ.
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque
formation, secondary pathology, and premature death.
Neuron. 2003 Dec 18;40(6):1087-93.
PMID: 14687544 [PubMed - indexed for MEDLINE]
2: Leissring MA, Lu A, Condron MM, Teplow DB, Stein RL, Farris W, Selkoe DJ.
Kinetics of amyloid beta-protein degradation determined by novel fluorescence-
and fluorescence polarization-based assays.
J Biol Chem. 2003 Sep 26;278(39):37314-20. Epub 2003 Jul 16.
PMID: 12867419 [PubMed - indexed for MEDLINE]
3: Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M,
Anliker B, Muller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM.
A physiologic signaling role for the gamma -secretase-derived intracellular
fragment of APP.
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4697-702.
PMID: 11917117 [PubMed - indexed for MEDLINE]
4. Sugarman MC, Yamasaki TR, Oddo S, Echegoyen JC, Murphy MP, Golde TE,
Jannatipour M, Leissring MA, LaFerla FM.
Inclusion body myositis-like phenotype induced by transgenic overexpression of
beta APP in skeletal muscle.
Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6334-9.
PMID: 11972038 [PubMed - indexed for MEDLINE]
5: Leissring MA, LaFerla FM, Callamaras N, Parker I.
Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling.
Neurobiol Dis. 2001 Jun;8(3):469-78.
PMID: 11442355 [PubMed - indexed for MEDLINE]
6: Marchant JS, Stutzmann GE, Leissring MA, LaFerla FM, Parker I.
Multiphoton-evoked color change of DsRed as an optical highlighter for cellular
and subcellular labeling.
Nat Biotechnol. 2001 Jul;19(7):645-9.
PMID: 11433276 [PubMed - indexed for MEDLINE]
7: LaFerla FM, Sugarman MC, Lane TE, Leissring MA.
Regional hypomyelination and dysplasia in transgenic mice with
astrocyte-directed expression of interferon-gamma.
J Mol Neurosci. 2000 Aug;15(1):45-59.
PMID: 11211236 [PubMed - indexed for MEDLINE]
8: Leissring MA, Yamasaki TR, Wasco W, Buxbaum JD, Parker I, LaFerla FM.
Calsenilin reverses presenilin-mediated enhancement of calcium signaling.
Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8590-3.
PMID: 10900016 [PubMed - indexed for MEDLINE]
9: Leissring MA, Akbari Y, Fanger CM, Cahalan MD, Mattson MP, LaFerla FM.
Capacitative calcium entry deficits and elevated luminal calcium content in
mutant presenilin-1 knockin mice.
J Cell Biol. 2000 May 15;149(4):793-8.
PMID: 10811821 [PubMed - indexed for MEDLINE]
10: Mattson MP, LaFerla FM, Chan SL, Leissring MA, Shepel PN, Geiger JD.
Calcium signaling in the ER: its role in neuronal plasticity and
neurodegenerative disorders.
Trends Neurosci. 2000 May;23(5):222-9. Review.
PMID: 10782128 [PubMed - indexed for MEDLINE]
11: Leissring MA, Parker I, LaFerla FM.
Presenilin-2 mutations modulate amplitude and kinetics of inositol 1,
4,5-trisphosphate-mediated calcium signals.
J Biol Chem. 1999 Nov 12;274(46):32535-8.
PMID: 10551803 [PubMed - indexed for MEDLINE]
12: Leissring MA, Paul BA, Parker I, Cotman CW, LaFerla FM.
Alzheimer's presenilin-1 mutation potentiates inositol
1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes.
J Neurochem. 1999 Mar;72(3):1061-8.
PMID: 10037477 [PubMed - indexed for MEDLINE]
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*Why* people without mutations get it. |
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