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| First Name: | Yusuf | | Last Name: | Hannun | | Title: | Ralph Hirschmann Professor and Chair | | Advanced Degrees: | M.D. | | Affiliation: | Medical University of South Carolina | | Department: | Biochemistry and Molecular Biology | | Street Address 1: | 175 Ashley Ave | | City: | Charleseton | | State/Province: | SC | | Zip/Postal Code: | 29425 | Country/Territory: | U.S.A. | | Phone: | 843 792 9318 | | Fax: | 843 792 4322 | | Email Address: |  |
Disclosure:
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Member reports no financial or other potential conflicts of interest. [Last Modified: 2 March 2004]
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View all comments by Yusuf Hannun
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sphingolipids, Apoptosis/Cell cycle, Oxidative Stress, Signal transduction
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1. Hannun, Y., Loomis, C. Merrill, A. and Bell, R. (1986) Sphingosine Inhibition of Protein Kinase C Activity and of Phorbol Dibutyrate Binding In Vitro and in Human Platelets. J. Biol. Chem. 261, 12604-12609.
2. Hannun, Y., and Bell, R. (1987) Lysosphingolipid Inhibition of Protein Kinase C: Implications in the Pathogenesis of the Sphingolipidoses. Science 235, 670-674 (1987).
3. Okazaki, T., Bell, R. and Hannun, Y. (1989) Sphingomyelin Turnover Induced by Vitamin D3 in HL-60 Cells: Role in Cell Differentiation. J. Biol. Chem. 264, 19076-19080.
4. Okazaki, T., Bielawska, A., Bell, R. and Hannun, Y. (1990) Role of Ceramide as a Second Messenger in HL-60 Cell Differentiation Induced by 1a,25-dihydroxyvitamin D3 J. Biol. Chem 265, 15823-15831.
5. Kim, M-Y., Linardic, C., Obeid, L., and Hannun, Y. (1991) Identification of Sphingomyelin Turnover as an Effector Mechanism for the Action of TNF a and g Interferon; Specific Role in Cell Differentiation. J. Biol. Chem. 266, 484-489.
6. Dobrowsky, R.T., and Hannun, Y.A. (1992) Ceramide Stimulates a Cytosolic Protein Phosphatase. J. Biol. Chem. 267, 5048-5051.
7. Obeid, L.M., Linardic, C.M., Karolak, L.A., and Hannun, Y.A. (1993) Programmed Cell Death Induced by Ceramide. Science 259, 1769-1771.
8. Dobrowsky, R.T., Werner, M.H., Castellino, A.M., Chao, M.V., and Hannun, Y.A. (1994) Activation of the Sphingomyelin Cycle Through the Low Affinity Neurotrophin Receptor. Science 265, 1596-1599.
9. Hannun, Y.A., (1996) Functions of Ceramide in Coordinating Cellular Responses to Stress. Science 274, 1855-1859.
10. Cowart, L. A., Okamoto, Y., Pinto, F. R., Gandy, J. L., Almeida, J., and Hannun, Y. A. (2003) Roles for Sphingolipid Biosynthesis in Mediation of Specific Programs of the Heat Stress Response Determined Through Gene Expression Profiling J. Biol. Chem.278: 30328-30338.
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ceramide mediates responses to various stresses including oxidative stress |
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