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| First Name: | Dominic | | Last Name: | Walsh | | Title: | Associate Professor | | Advanced Degrees: | Ph.D. | | Affiliation: | Brigham & Women's Hospital | | Department: | Laboratory for Neurodegenerative Research | | Street Address 1: | Harvard Institutes of Medicine | | Street Address 2: | 77 Avenue Louis Pasteur | | City: | Boston | | Zip/Postal Code: | 02115 | Country/Territory: | U.S.A. | | Phone: | 1 617 525 5059 | | Fax: | 1 617 525 5252 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 11 October 2011]
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View all comments by Dominic Walsh
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Aging Process, Prion Diseases, Tauopathies, Parkinson Disease, Alzheimer Disease
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Electrophysiology, Neurobiology, A-beta PP/A-beta, Protein structure/chemistry, Molecular and Cell biology, Signal transduction, Animal Models, Tau/Cytoskeleton
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Medical hospital, University
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Postdoctoral Employment
1992-1995: Postdoctoral Research Fellow in Biochemistry, The Queen's University of Belfast.
Project: "An investigation of the proteolytic cleavage of Alzheimer's APP". As a member of the research group lead by Dr. David Allsop.
1995-1998: Postdoctoral Research Fellow in Neurology. Harvard Medical School & Brigham and Women's Hospital. Project: "Fibrillogenic properties of amyloid β peptides." As a member of the groups lead by Prof. Dennis Selkoe and Dr. David Teplow.
1998: Instructor in Neurology
Harvard Medical School & Brigham and Women's Hospital
2003-2006: Wellcome Trust Senior Research Lecturer, University College Dublin.
2006-2011: Associate Professor of Neurodegeneration, University College Dublin.
2011- Associate Professor (Neurology), Brigham and Women's Hospital & Harvard Medical School.
Professional Activities
Member: Biochemical Society (1990-) and the Society for Neuroscience (1998-)
Editorial Advisor: Biochemical Journal, 2010-.
Grant reviewer: Alzheimer’s Association (USA) 1999 - 2010.
Grant reviewer: Wellcome Trust 2002, 2003, 2004, 2005 and 2006.
Grant reviewer: European Science Foundation 2004.
Grant reviewer: John Sealy Memorial Endowment Fund for Biomedical Research 2004.
Grant reviewer: Alzheimer’s Society (UK) 2004 and 2005.
Grant reviewer: Alzheimer’s Research Trust (UK) 2006.
Grant reviewer: United States-Israel Binational Science Foundation 2006.
Grant reviewer: Science Foundation Ireland 2006.
Grant reviewer: UCD Seed Funding Scheme 2006.
Committee Chair: UCD Seed Funding Scheme 2007-9.
Grant reviewer: Washington University ADRC Funding Scheme 2007.
Grant reviewer: Mayo Clinic Alzheimer’s disease Research Center Funding Scheme 2007.
Grant reviewer: Alzheimer Forschung Initiative e.V., Germany 2007.
Grant reviewer: American Health Assistance Foundation, USA 2008.
Grant reviewer: Qatar National Research Fund, Qatar 2008.
Grant reviewer: Italian Telethon Foundation 2008.
Grant reviewer: Agence Nationale de la Recherche (French National Research Agency) 2010.
Meetings correspondent: Alzheimer Research Forum 1999, 2000, 2001, 2002 and 2003. International advisory board member: Alzheimer Research Forum 2004.
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1. Brian O'Nuallain, Darragh B. Freir, Andrew J. Nicoll, Emmanuel Risse, Neil Ferguson, Caroline E. Herron, John Collinge and Dominic M. Walsh (2010) Abeta dimers rapidly form stable synaptotoxic protofibrils. Journal of Neuroscience 30: 14411-14419.
2. Jessica M. Mc Donald, George M. Savva, Carol Brayne, Alfred T. Welzel, Gill Forster, Ganesh M. Shankar, Dennis J. Selkoe, Paul G. Ince and Dominic M. Walsh (2010) The presence of SDS-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain 133: 1297-1311.
3. Vicki Betts, Malcolm A. Leissring, Susi Keck, Georgia Dolios, Rong Wang, Dennis J. Selkoe and Dominic M. Walsh (2008) Aggregation and catabolism of disease-associated intra- Abeta mutations: reduced proteolysis of Abeta A21G by neprilysin. Neurobiology of Disease 31: 442-450.
4. Ganesh M. Shankar, Shaomin Li, Tapan H. Mehta, Amaya Garcia-Munoz, Nina E. Shepardson, Imelda M. Smith, Francesca M. Brett, Michael A. Farrell, Michael J. Rowan, Cindy A. Lemere, Ciaran M. Regan, Dominic M. Walsh, Bernardo L. Sabatini and Dennis J. Selkoe (2008) Amyloid-beta oligomers isolated directly from the brains of Alzheimer disease patients potently impair synaptic structure and plasticity and learned behavior. Nature Medicine 14:837-42.
5. Igor Klyubin, Vicki Betts, Alfred Welzel, Kaj Blennow, Henrik Zetterberg, Anders Wallin, Cynthia A. Lemere, William K. Cullen, Ying Peng, Thomas Wisniewski, Dennis J. Selkoe, Roger Anwyl, Dominic M. Walsh and Michael J. Rowan (2008) Abeta dimers in human cerebrospinal fluid disrupt synaptic plasticity: prevention by systemic passive immunization. Journal of Neuroscience 28:4231-7.
6. Dominic M. Walsh, Matthew Townsend, Marcia B. Podlisny, Ganesh M. Shankar, Julia V. Fadeeva, Omar El Agnaf, Dean M. Hartley and Dennis J. Selkoe (2005) Certain inhibitors of synthetic Abeta fibrillogenesis block oligomerization of natural Abeta and thereby rescue long term potentiation. Journal of Neuroscience 25: 2455-2462.
7. Dominic M. Walsh, Igor Klyubin, Julia V. Fadeeva, Roger Anwyl, Michael S. Wolfe, Michael J. Rowan and Dennis J. Selkoe. (2002). Naturally secreted oligomers of amyloid beta -protein potently inhibit hippocampal LTP in vivo. Nature 416: 535-539.
8. Dominic M. Walsh, Dean M. Hartley, Yoko Kusumoto, Youcef Fezoui, Aleksey Lomakin, George B. Benedek, Margret M. Condron, Dennis J. Selkoe and David B. Teplow (1999) Amyloid beta-protein fibrillogenesis: structure and biological activity of protofibrillar intermediates. Journal of Biological Chemistry 274: 25945-25952.
9. Dominic M. Walsh, Aleksey Lomakin, George B. Benedek, Margret M. Condron and David B. Teplow (1997) Amyloid betaprotein fibrillogenesis: detection of a protofibrillar intermediate. Journal of Biological Chemistry 272: 22364-22372.
10. Dominic M. Walsh, Carvell H. Williams, Hilary E. Kennedy, Gillian Murphy and David Allsop (1994) Gelatinase A not alpha-secretase? Nature 367: 27-28.
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Itner et al. 2010 Cell
Cisse et al. 2011 J Neuroscience
Emmanouilidou et al. 2010 J Neuroscience
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