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Home: Community: Researcher Profiles
Researcher Profile

RESEARCHER INFORMATION
First Name:Jun
Last Name:Xu
Title:Dr.
Advanced Degrees:MD PhD
Affiliation:Nanjing Brain Hospital
Department:Neurology
Street Address 1:264 Guangzhou Road
Street Address 2:Building 3 Floor 4
City:Nanjing
State/Province:Jiangsu
Zip/Postal Code:210029
Country/Territory:China
Phone:86-25-82296226
Fax:86-25-8371-2308
Email Address: 
Disclosure:
(view policy) 
Member reports no financial or other potential conflicts of interest. [Last Modified: 11 March 2011]
View all comments by Jun Xu
Clinical Interests:
Aging Process, Neuromuscular Disorders (ALS, etc.), Polyglutamine Disorders (Huntington's, etc.), Tauopathies, Prion Diseases, Parkinson Disease, Alzheimer Disease, Neurodevelopmental Disorders (Down syndrome, etc.), Stroke and Trauma
Research Focus:
Neuroimmunology, Microscopy, Protein structure/chemistry, Genetics, A-beta PP/A-beta, Proteomics, Stem cells, Animal Models, Epidemiology, Molecular and Cell biology, Apoptosis/Cell cycle, Neurobiology, Neuropathology, Diagnosis, Signal transduction, Tau/Cytoskeleton, Brain imaging
Work Sector(s):
Medical hospital, Research institute, University
Web Sites:
Personal: http://blog.163.com/neurojun@126/
Professional: http://www.c-nbh.com/
Researcher Bio
Research & Training Experience
2003.9-2006.1: Research Associate
Department of Pathology,
Hillman Cancer Center, University of Pittsburgh
Pittsburgh, PA, 15232 USA
• Natural Killer Cells-Dendritic Cells Interaction by Tumor Necrosis Factor Super family Ligand-receptor
• Impaired Tumoricidal Activity of Dendritic Cells in Head Neck Cancer Patients
• Brain Protecting Receptors (CD56) on Natural Killer Cells
• Antitumor Activity of Dendritic Cells
2003.4-2003.8: Postdoctoral Fellow
Department of Pathology,
Hillman Cancer Center, University of Pittsburgh
Pittsburgh, PA, 15232 USA
• Apoptosis Mechanism of Breast Cancer Cells
• ER Stress & Mitochondria Dysfunction
1999.9-2002.7: Ph.D.,
Neurology & Neuroscience,
Dept. of Neurology, The first affiliated hospital,
Sun Yat-Sen University of Medical Sciences,
Guangzhou, Guangdong, P.R.China. 510080
Working Experience
2007.6-present: Associate Professor
Vice Dean, Dept. of Neurology,
Deputy Director, Nanjing Neurology & Psychiatry Institute,
Affiliated Nanjing Brain Hospital
Nanjing Medical University
264 Guangzhou Road
Nanjing, JIangsu 210029
2006.2-2007.6: Clinical Associate Professor
Dept. of Geriatrics & Neurology,
The Affiliated Guangzhou Municipal First People’s Hospital,
Guangzhou Medical College,
Guangzhou, Guangdong, P.R.China. 510180
2002.7-2003.3: Attending Physician
Dept. of Geriatrics & Neurology,
The Affiliated Guangzhou Municipal First People’s Hospital,
Guangzhou Medical College,
Guangzhou, Guangdong, P.R.China. 510180
1994.7-1996.8: Residency
Dept. of Neurology,
The Affiliated Second Hospital,
Xuzhou Medical College,
Xuzhou, Jiangsu, P.R.China. 221000
Top Papers
1. Cognition improvement with intrathecal administration of infliximab in a woman with Alzheimer's disease. JAGS-0107-L-Jan-11.R1 (Accepted)
2. Shi JQ, Shen W, Chen J, Wang BR, Zhong LL, Zhu YW, Zhu HQ, Zhang QQ, Zhang YD, Xu J. Anti-TNF-a reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains. Brain Res. 2011, 1368(1): 239-247

3. Jun Xu, Ayan Chakrabarti, Jennifer A Liberatore, et al. TNF-TNFR2 cognate interaction in mouse dendritic cell–natural killer cell crosstalk. Blood. 2007; 109(8):3333-3341
4. Li S, Xu J, Makarenkova VP, et al. A novel epitope of N-CAM defines precursors of human adherent NK cells. J Leuko Biol. 2004, 76(6):1187-1199

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