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| First Name: | Xianlin | | Last Name: | Han | | Title: | Associate Professor of Medicine | | Advanced Degrees: | Ph.D. | | Affiliation: | Washington University School of Medicine in St. Louis | | Department: | Internal Medicine | | Street Address 1: | Box 8020 | | Street Address 2: | 660 S. Euclid Ave. | | City: | St. Louis | | State/Province: | MO | | Zip/Postal Code: | 63110 | Country/Territory: | U.S.A. | | Phone: | 314/747-2877 | | Fax: | 314/362-1402 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 12 April 2008]
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View all comments by Xianlin Han
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Polyglutamine Disorders (Huntington's, etc.), Alzheimer Disease, Neurodevelopmental Disorders (Down syndrome, etc.), Neuromuscular Disorders (ALS, etc.), Stroke and Trauma, Aging Process, Prion Diseases, Tauopathies, Parkinson Disease
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Electrophysiology, Lipidomics, Molecular and Cell biology, Chemistry/Pharmacology, Proteomics, Signal transduction, Neurobiology, Neuropathology, Diagnosis, Tau/Cytoskeleton, Animal Models, A-beta PP/A-beta, Apoptosis/Cell cycle, Clinical trials, Oxidative Stress, Protein structure/chemistry
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Zhejiang University, P.R. China B.S. 1982 Chemistry
Zhejiang University, P.R. China M.S. 1985 Physical Chemistry
Washington University, St. Louis, MO M.A. 1987 Physical Chemistry
Washington University, St. Louis, MO Ph.D. 1990 Biophysical Chemistry
1990 – 1992 Research Associate, Bioorganic Chemistry and Molecular Pharmacology, Washington University, St. Louis, MO
1992 – 1997 Research Instructor, Bioorganic Chemistry and Molecular Pharmacology, Washington University, St. Louis, MO
1997 – 2000 Research Assistant Professor, Bioorganic Chemistry and Molecular Pharmacology, Washington University, St. Louis, MO
2000 – Present Assistant Professor, Internal Medicine, Washington University, St. Louis, MO
Professional Memberships:
American Chemical Society
American Association for the Advancement of Science
The American Society for Biochemistry and Molecular Biology
The Society for Neuroscience
The American Society for Mass Spectrometry
International Society for Mass Spectrometry
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1. Han, X., Holtzman, D.M., and McKeel, D. (2001) Plasmalogen deficiency in early Alzheimer’s disease subjects and in animal models: Molecular characterization using electrospray ionization mass spectrometry. J. Neurochem. 77, 1168-1180.
2. Han, X. and Gross, R.W. (2001) Quantitative analysis and molecular species fingerprinting of triacylglyceride molecular species directly from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry. Anal. Biochem. 295, 88-100.
3. Pike, L.J., Han, X., Chung, K.-N., Gross, R.W. (2002) Lipid rafts are enriched in arachidonic acid and plasmenylethanolamine and their composition is independent of caveolin-1 expression: A quantitative electrospray ionization/mass spectrometric analysis. Biochemistry 41, 2075-2088.
4. Han, X., Holtzman, D.M., McKeel Jr., D.W., Kelley, J., and Morris, J.C. (2002) Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer’s disease: Potential role in disease pathogenesis. J. Neurochem. 82, 809-818.
5. Han, X., Cheng, H., Fryer, J.D., Fagan, A.M., and Holtzman, D.M. (2003) Novel role for apolipoprotein E in the central nervous system: Modulation of sulfatide content. J. Biol. Chem. 278, 8043-8051.
6. Acharya, U., Patel, S., Koundakjian, E., Nagashima, K., Han, X., and Acharya, J.K. (2003) Modulation of sphingolipid biosynthetic pathway rescues photoreceptor degeneration. Science 299, 1740-1743.
7. Han, X. and Gross, R. W. (2003) Global analyses of cellular lipidomes directly from crude extracts of biological samples by electrospray ionization mass spectrometry: A bridge to lipidomics. J. Lipid Res. 44, 1071-1079.
8. Han, X., Fagan, A.M., Morris, J. C., Xiong, C., and Holtzman, D.M. (2003) CSF sulfatide is decreased in individuals with mild cognitive impairment/very mild dementia. Ann. Neurol. 54, 115-119.
9. Cheng, H., Xu, J., McKeel Jr., D.W., and Han, X. (2003) Specificity and potential mechanism of sulfatide deficiency in Alzheimer’s disease: An electrospray ionization mass spectrometric study. Cell. Mol. Biol. In press.
10. Lee, J.-T., Xu, J., Yang, D.-I., Ku, G., Han, X., and Hsu, C.-Y. (2003) Amyloid beta peptides induce cell death through activation of neutral sphingomyelinase-ceramide pathway in oligodendrocytes in culture. J. Cell. Biol. In press
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Unified theory and effective biomarkers |
1. Daniel Figeys (2003) Proteomics in 2002: A year of technical development and wide-ranging applications. Anal. Chem. 75, 2891-2905.
2. Growdon, J.H. (1999) Biomarkers of Alzheimer's disease. Arch. Neurol. 56, 281-283.
3. Emmerling, M.R., Gracon S., and Roher A.E. (1999) Towards a unifying hypothesis of Alzheimer's disease pathogenesis and pathophysiology. In "Clinical Diagnosis and management og Alzheimer's disease". 2ed edtion (Gauthier S., ed.). |
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