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| First Name: | Chris | | Last Name: | Norris | | Title: | Assistant Professor | | Advanced Degrees: | PhD | | Affiliation: | University of Kentucky College of Medicine | | Department: | Sanders-Brown Center on Aging/Dept. Pharmacology | | Street Address 1: | 131 Sanders Brown Building | | City: | Lexington | | State/Province: | KY | | Zip/Postal Code: | 40536 | Country/Territory: | U.S.A. | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 8 April 2010]
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View all comments by Chris Norris
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Aging Process, Alzheimer Disease
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Neurobiology, Neurotransmission, Signal transduction, Neuroimmunology
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Ph.D.Neuroscience, May, 1998, University of Virginia
Doctoral Thesis: “Changes in hippocampal synaptic function during aging”
Advisor: Dr. Thomas C. Foster
Post Doc: Neurobiology of Aging, 1998-2003, Univ. of Kentucky
Research: L-type Ca2+ channel regulation in hippocampal cultures by the protein phosphatase, calcineurin
Advisor: Dr. Philip Landfield
2004-present Assistant Professor, Department of Molecular and Biomedical Pharmacology and the Sanders-Brown Center on Aging, University of Kentucky College of Medicine
Research interests: Calcium signaling mechanisms in aging, neuroinflammation, and Alzheimer's disease. |
Norris CM, Korol DL, Foster TC. Increased susceptibility to induction of long-term depression and long-term potentiation reversal during aging. The Journal of Neuroscience 16:5382-5392. 1996. PMID: 8757251
Norris CM, Halpain S, Foster TC. Reversal of age-related alterations in synaptic plasticity by blockade of L-type Ca2+ channels. The Journal of Neuroscience 18:3171-3179. 1998. PMID: 9547225
Norris CM, Halpain S, Foster TC. Alterations in the balance of protein kinase/phosphatase activities parallel reduced synaptic strength during aging. Journal of Neurophysiology 80:1567-1570. 1998. PMID: 9744962
Norris CM, Kadish I, Blalock EM, Chen, K-C, Thibault V, Porter, NM, Landfield PW, Kraner SD. Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer’s models. The Journal of Neuroscience 25:4649-4658. 2005. PMID: 15872113
Sama MA, Mathis DM, Furman JL, Artiushin IA, Mohmmad Abdul H, Kraner SD, Norris CM. Interleukin-1beta-dependent signaling between glia and neurons depends critically on astrocytic calcineurin/NFAT activity. The Journal of Biological Chemistry 283:21953-64. 2008. PMID: 18541537
Norris CM, Blalock EM, Chen K-C, Porter, NM, Thibault O, Kraner SD, Landfield PW. Hippocampal ‘zipper’ slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca2+ channels with aging. Neurobiology of Aging 31:328–338. 2010 PMID: 18471936
Abdul MH, Sama MA, Furman JL, Mathis DM, Weidner AM, Levine, H III, Beckett TL, Murphy MP, Kraner SD, Norris CM. Cognitive decline in Alzheimer’s disease is associated with selective changes in calcineurin/ NFAT signaling. The Journal of Neuroscience 29:12957–12969. 2009. PMID: 19828810
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