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| First Name: | Mark | | Last Name: | Cookson | | Advanced Degrees: | PhD | | Affiliation: | National Institute on Aging | | Department: | Laboratory of Neurogenetics | | Street Address 1: | Building 10, Room 6C103 | | Street Address 2: | 900 Rockville Pike | | City: | Bethesda | | State/Province: | MD | | Zip/Postal Code: | 20008 | Country/Territory: | U.S.A. | | Phone: | 301 451 3870 | | Fax: | 301 480 0315 | | Email Address: |  |
Disclosure:
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View all comments by Mark Cookson
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Molecular and Cell biology, Protein structure/chemistry, Proteomics, Genetics, Microscopy, Neurobiology, DNA microarrays
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Dr. Mark R. Cookson is a cell biologist whose current research interests include the effects of mutations in the genes associated with neurodegeneration at the cellular and molecular level. His laboratory efforts are directed at finding the underlying pathways that lead to neuronal dysfunction and cell death. Dr. Cookson received both his B.Sc. and Ph.D. degrees from the University of Salford, UK in 1991 and 1995, respectively. His postdoctoral studies included time spent at the Medical Research Council laboratories and at the University of Newcastle, Newcastle, UK. He joined the Mayo Clinic, Jacksonville, Florida, as an Assistant Professor in 2000 and moved to the NIA in February 2002. Within the Laboratory of Neurogenetics, Dr. Cookson’s group will continue to work on movement disorders such as Parkinson’s disease and dystonia, attempting to understand mechanisms leading to neuronal damage.
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1: Cookson MR. Pathways to parkinsonism.
Neuron. 2003 Jan 9;37(1):7-10.
PMID: 12526767 [PubMed - in process]
2: Petrucelli L, O'Farrell C, Lockhart PJ, Baptista M, Kehoe K, Vink L, Choi P, Wolozin B, Farrer M, Hardy J, Cookson MR. Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons.
Neuron. 2002 Dec 19;36(6):1007-19.
PMID: 12495618 [PubMed - indexed for MEDLINE]
3: Allen S, Heath PR, Kirby J, Wharton SB, Cookson MR, Menzies FM, Banks RE, Shaw PJAnalysis of the cytosolic proteome in a cell culture model of familial amyotrophic lateral sclerosis reveals alterations to the proteasome, antioxidant defenses, and nitric oxide synthetic pathways.
J Biol Chem. 2003 Feb 21;278(8):6371-83.
PMID: 12475980 [PubMed - in process]
4: Sherer TB, Betarbet R, Stout AK, Lund S, Baptista M, Panov AV, Cookson MR, Greenamyre JT. An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.
J Neurosci. 2002 Aug 15;22(16):7006-15.
PMID: 12177198 [PubMed - indexed for MEDLINE]
5: Kirby J, Menzies FM, Cookson MR, Bushby K, Shaw PJ. Differential gene expression in a cell culture model of SOD1-related familial motor neurone disease.
Hum Mol Genet. 2002 Aug 15;11(17):2061-75.
PMID: 12165567 [PubMed - indexed for MEDLINE]
6: Menzies FM, Cookson MR, Taylor RW, Turnbull DM, Chrzanowska-Lightowlers ZM, Dong L, Figlewicz DA, Shaw PJ. Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis.
Brain. 2002 Jul;125(Pt 7):1522-33.
PMID: 12077002 [PubMed - indexed for MEDLINE]
7: O'Farrell C, Murphy DD, Petrucelli L, Singleton AB, Hussey J, Farrer M, Hardy J, Dickson DW, Cookson MR. Transfected synphilin-1 forms cytoplasmic inclusions in HEK293 cells.
Brain Res Mol Brain Res. 2001 Dec 16;97(1):94-102.
PMID: 11744167 [PubMed - indexed for MEDLINE]
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