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Home: Community: Researcher Profiles
Researcher Profile

RESEARCHER INFORMATION
First Name:Zuoshang
Last Name:Xu
Title:Associate Professor
Advanced Degrees:Ph.D.
Affiliation:University of Massachusetts Medical School
Department:Biochemistry and Molecular Pharmacology
Street Address 1:364 Plantation Street
Street Address 2:817 LRB
City:Worcester
State/Province:MA
Zip/Postal Code:01536
Country/Territory:U.S.A.
Disclosure:
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Clinical Interests:
Aging Process, Polyglutamine Disorders (Huntington's, etc.), Alzheimer Disease, Prion Diseases, Neurodevelopmental Disorders (Down syndrome, etc.), Stroke and Trauma, Neuromuscular Disorders (ALS, etc.), Parkinson Disease, Tauopathies
Research Focus:
Oxidative Stress, Signal transduction, Neurobiology, Molecular and Cell biology, Neuropathology
Work Sector(s):
University
Top Papers
Kong J-M, Tung V, Aghjanian J and Xu ZS (1998) Antagonistic roles between neurofilament subunits NF-H/NF-M and NF-L in shaping dendritic arborization in spinal cord motor neurons. J Cell Biol 140: 1167-76.
Kong J-M and Xu ZS (1998) Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1. J Neurosci, 18: 3241-3250.
Levine J, Kong J-M and Xu ZS (1999) Astrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis (ALS). Glia 28: 215-224.
Xu ZS and Tung V (2001) Temporal and spatial variations in slow axonal transport velocity along peripheral motoneuron axons. Neuroscience 102: 193-200.
Higgins CJM, Jung C, Ding HL and Xu ZS (2002) Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the central nervous system. J Neurosci RC215:1-6.
Zhang Z, Casey D, Julien J-P and Xu ZS (2002) Neurofilament subunit L (NF-L) is required for normal development of motoneuron dendrite. J Comp Neurol 450:144-52.
Jung C, Higgins CJM and Xu ZS (2002) Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis. J Neurochem 83: 535-45.

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