Researcher Bio Hugo Geerts is currently Chief Scientific Officer of In Silico Biosciences, a company that provides mechanistic disease modeling services in CNS Drug discovery & Development. After an undergraduate degree in physics (with emphasis on theoretical quantum-mechanics) and a PhD in Biophysics he got a Bachelor Degree in Medicine, a Master in Pharmaceutical Sciences, and a Pharma Executive MBA at the Drexel University in Philadelphia. He worked for 17 years with Dr. Paul Janssen, probably the greatest drug hunter in history at the Janssen Research Foundation (part of J&J) where he was involved in Alzheimer research and supported the succesfull clinical development of galantamine. His is passionate about the need for more integrated modeling & simulation along the whole Drug R&D process to reduce the failure rate of clinical trials and to get better drugs faster to the right patients. He is currently also Adjunct Associate Professor in the School of Medicine at the University of Pennsylvania.
What is the greatest void to date in our knowledge of Alzheimer's Disease? I think the biggest void is the immensely(large) gap between molecular biochemical processes such as amyloid-beta modulation or tangle formation and the functional cognitive performance of the patient. I am a great fan of bringing the community of cognitive neuroscience togetehr with the community of Alzheimer researchers. As long as we don't get a better insigth on the relation of nejuronal cell pathology to emergent properties of networks, we won't be able to make real progress in treating this disease