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| First Name: | Martin | | Last Name: | Sadowski | | Title: | Assistant Professor | | Advanced Degrees: | MD, PhD | | Affiliation: | New York University School of Medicine | | Department: | Neurology and Psychiatry | | Street Address 1: | 550 First Ave. | | Street Address 2: | MHL Rm. HN419 | | City: | New York | | State/Province: | NY | | Zip/Postal Code: | 10016 | Country/Territory: | U.S.A. | | Phone: | 212 263 0984 | | Fax: | 212 263 7528 | | Email Address: |  |
Disclosure:
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Member reports no financial or other potential conflicts of interest. [Last Modified: 11 December 2006]
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View all comments by Martin Sadowski
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Aging Process, Alzheimer Disease, Prion Diseases
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A-beta PP/A-beta, Animal Models, Neurobiology, Diagnosis, Microscopy, Brain imaging, Chemistry/Pharmacology, Protein structure/chemistry, Proteomics, Clinical trials, Neuropathology
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University, Medical hospital
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Marcin Sadowski, M.D., Ph.D. is an Assistant Professor of Neurology and Psychiatry in New York University (NYU) School of Medicine. He is an attending physician in the NYU Medical Center, Bellevue Hospital Center, and in Manhattan VA Medical Center. He is also the Director of Neurological Service in the Center for Brain Health in NYU and Director of Geriatric Neurology Fellowship.
Dr. Sadowski graduated from Medical University of Gdansk in Gdansk, Poland in 1995 and received Ph.D. in neuroanatomy from the same institution in 1996. Between 1996 and 1998 he completed post-doctoral fellowship in experimental neuropathology in the New York State Institute for Basic Research. Following an internship in general medicine, Dr. Sadowski completed a neurology residency in New York Medical College and NYU School in Medicine and joined NYU faculty as an Assistant Professor in 2002.
Dr. Sadowski research focuses on Alzheimer’s disease, the most common form of dementia, and on prion diseases, which although relatively rare grasp a broad attention of the general public. Both Alzheimer’s disease and prion disease belong to a group of conformational disorders where pathological mechanism lies upon conversion of physiological proteins into insoluble and toxic conformers accumulating in the brain during the course of the disease. Dr. Sadowski is using cell culture and transgenic animal models to study various aspects of pathological mechanisms of these diseases. He is also using these models to test various diagnostic and treatment approaches which may be applicable for human use. In particular Dr. Sadowski is working on inhibition an interaction between amyloid- peptide and apolipoprotein E which chaperones conformational transformation of amyloid- and facilitates its deposition in the brain of Alzheimer’s patients. Dr. Sadowski is also developing new MRI and PET ligands allowing detection of accumulation of abnormal prion protein in infected but presymptomatic patients. Clinical research of Dr. Sadowski focuses on memory dysfunction during normal aging, mild cognitive impairment and its conversion to Alzheimer’s disease.
Dr. Sadowski’s clinical practice consists primarily of patients with memory problems and dementia. He sees patients in the Memory and Dementia Center in NYU, and in the multidisciplinary memory clinic in Manhattan VA Medical Center. As a Director of Neurological Service Dr. Sadowski is also responsible for neurological care of patients evaluated in the Center for Brain Health, which is a research program focusing on development and validation biomarkers for Alzheimer’s disease, clinical drug trials, and on longitudinal studies on memory changes during normal aging, mild cognitive impairment and its conversion to Alzheimer’s disease. Dr. Sadowski is an author of a book directed to patients and their caregivers entitled “100 Questions and Answers About Alzheimer’s Disease”. Dr. Sadowski enjoys teaching medical students, residents and is the Director of Geriatric Neurology Fellowship in NYU.
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1. Sadowski M, Tang CY, Aguinaldo G, Carp R, Meeker HC, Wisniewski T. In vivo MRI signal changes in scrapie infected mice. Neurosc. Lett. 2003; 345:1-4.
2. Wadghiri YZ, Sigurdsson EM, Sadowski M, Elliott JI, Li YS, Scholtzova H, Tang CY, Aguinaldo G, Pappolla M, Duff K, Wisniewski T, Turnbull DH. Detection of Alzheimer's amyloid in Transgenic mice using magnetic resonance microimaging. Magn Reson Med 2003; 50:293-302
3. Sadowski M, Pankiewicz J, Scholtzova H, Li Y-S, Quartermain D, Duff K, Wisniewski T Links between the pathology of Alzheimer’s disease and vascular dementia. Neurochemical Res. (2004) 29(6): 1257-1266.
4. Sadowski M, Pankiewicz J, Scholtzova H, Quartermain D, Jensen CH, Duff K, Nixon RA, Gruen RJ, Wisniewski T. Amyloid- deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice. J Neuropath Exp Neurol (2004) 63(5) 418-428.
5. Sadowski M, Pankiewicz J, Scholtzova H, Ripellino J, Schmidt SD, Mathews PM, Sigurdsson EM, Holtzman D, Wisniewski T. A synthetic peptide blocking the apolipoprotein E/-amyloid binding mitigates -amyloid toxicity and fibril formation in vitro and reduces -amyloid plaques in transgenic mice. Am. J. Pathol. (2004) 165(3): 937-948.
6. Sadowski M, Pankiewicz J, Scholtzova H, Tsai J, Carp RI, Meeker CH, Gan WB, Klunk WE, Wisniewski T. Targeting priom amyloid deposits in vivo. J Neuropath Exp Neurol (2004) 63(7):775-784.
7. Sadowski M, Kumar A, Wisniewski T, “Prion diseases”. In Bradley,WG (Ed.), Neurology in Clinical Practice Butterworth-Heinemann, 2003. Chapter 59G, 1613-1630.
8. Sadowski M, Wisniewski T. 100 Questions and answers about Alzheimer’s disease. Barlett and Jones Publishers, Boston, 2004.
9. Sadowski M, Wisniewski T. Vaccines for conformational disorders. Expert Rev. Vaccines (2004); 3(3) 279-290.
10. Sadowski M, Wisniewski T. Apolipoproteins in different amyloidoses. In Uversky VN (Ed) “Protein Misfolding, Aggregation and Conformational Diseases” Chapter I. 6., Kluver Academic/Plenum Publishers (in press).
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