(lab of Chris Dealwis,
Univ. of Tennessee, Knoxville, TN)
Formulation: liquid, protein-A affinity purified
Reacts in: Human
immunogen = CLC-stabilized protofibril form of Aβ(1–40); epitope within Aβ(1–8); DAEFRHDS, at the N terminus
The Fab fragments exhibit binding to Aβ monomers in the 20–40 nM range, and this binding is significantly impaired or eliminated in Aβ(1–40) mutants in which a single residue in the 3–7 segment is replaced with alanine. The full IgG molecules bind significantly better than Fab fragments to Aβ fibrils and protofibrils (0.1–0.2 nM); PFA1 binds more tightly to fibrils than does PFA2. diminished affinity for pyroglutamate-Glu forms of Aβ
- Gardberg AS, Dice LT, Ou S, Rich RL, Helmbrecht E, Ko J, Wetzel R, Myszka DG, Patterson PH, Dealwis C. Molecular basis for passive immunotherapy of Alzheimer's disease. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15659-64. PubMed.
No Available Further Reading