Antibody

β-Amyloid oligomers (NU-1)

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Clonality: monoclonal
Host: Mouse
Methods: DB, WB
Source: Mary Lambert
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

The immunogen is Aβ oligomers, specifically amyloid β-derived diffusible ligands (ADDLs), mixed with Freund's adjuvant

Specificity

Strong preferential binding for Aβ oligomers over monomers; neutralizes binding of endogenous and synthetic ADDLs to cultured cells; binds strongly to Alzheimer's disease brain samples but not to control brain samples; reactivity prominent in the hippocampus, entorhinal cortex, and middle frontal gyrus of Alzheimer's disease brain

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Further Reading

Papers

  1. . Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease. J Neurosci. 2008 Oct 22;28(43):10786-93. PubMed.
  2. . Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic. J Neurosci. 2008 Nov 5;28(45):11650-61. PubMed.
  3. . A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J Neurosci. 2010 Apr 7;30(14):4845-56. PubMed.