Antibody

β-Amyloid oligomers (NU-1)

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Clonality: monoclonal
Host: Mouse
Methods: DB, WB
Source: anti β-Amyloid oligomers
(paper, Mary Lambert et al.,
Northwestern University, Evanston, IL, USA)
References:
Varvel, 2009
Jimenez, 2008
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

immunogern = Aβ oligomers (amyloid β-derived diffusible ligands, ADDLs), mixed with Freund's adjuvant (we suggest that the NU-1 and NU-4 epitope is three-dimensional, in which aggregation of Aβ1–28 to form a dimer is necessary to align correct amino acids in the binding pocket, perhaps several from each single peptide)

Specificity

strong preferential binding for Aα oligomers over monomers; neutralizes binding of endogenous and synthetic ADDLs to cultured cells; binds strongly to Alzheimer's disease brain samples but not to control brain samples; reactivity prominent in the hippocampus, entorhinal cortex, and middle frontal gyrus of Alzheimer's disease brain

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References

Paper Citations

  1. . Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease. J Neurosci. 2008 Oct 22;28(43):10786-93. PubMed.
  2. . Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic. J Neurosci. 2008 Nov 5;28(45):11650-61. PubMed.

External Citations

  1. paper

Further Reading

No Available Further Reading