Antibody

β-Amyloid, N-terminal truncated (1-57)

Tools

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Clonality: monoclonal
Host: Mouse
Isotype: IgG2b
Methods: IH, WB
Source: Synaptic Systems
Cat# 218011
cell line 1-57
Reference:
Wirths, 2009
from the lab of Thomas Bayer
Formulation: affinity purified, buffered, azide, lyophilized
Reactivity:
Reacts in: Human, Mouse, Rat

Immunogen/Epitope

Balb/c mice were immunized with a KLH-coupled pyroglutamate-
Abeta-peptide with the peptide pE F R H D-C.
After preparation of the lymph nodes, cells were fused with the myeloma cell line P3-963-Ag8

Specificity

reactive to N-terminal truncated Abeta 3-X starting with pyroglutamate (pGlu, pE). Does not cross-react with N-terminal truncated Abeta 11-X starting with pGlu.

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References

Paper Citations

  1. . Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases. J Neural Transm. 2010 Jan;117(1):85-96. PubMed.

Further Reading

No Available Further Reading