Antibody

β-Amyloid (4G8)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG2b
Methods: ELISA, IH, IP, WB
Source: Covance Research Products, Inc.
Cat# SIG-39240
References:
Tian Y, 2010
Burton, 2008
Formulation: biotinylated IgG, PBS, no preservatives or carrier proteins
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

the epitope lies within amino acids 18-22 of beta amyloid (VFFAE)

Specificity

reactive to aa 17-24 Aβ and to APP

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References

Paper Citations

  1. . An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production. Nat Struct Mol Biol. 2010 Feb;17(2):151-8. PubMed.
  2. . The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression. J Biol Chem. 2008 Aug 22;283(34):22992-3003. PubMed.

Further Reading