β-Amyloid 1-16 or APP (6E10)


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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: ELISA, IH, WB
Source: Covance Research Products, Inc.
Cat# SIG-39330
Oddo, 2005
Caccamo, 2006
Deng, 2006
Rockenstein, 2007
Formulation: liquid, purified F(ab')2 frag of clone 6E10 monoclonal ab, PBS, no preservatives or carrier proteins
Reacts in: Human


epitope = lies within aa 3-8 of β-amyloid peptide (EFRHDS)


reactive to aa 1-16 of β-amyloid peptide (precursor forms and abnormally processed isoforms)

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Paper Citations

  1. . Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3046-51. PubMed.
  2. . M1 receptors play a central role in modulating AD-like pathology in transgenic mice. Neuron. 2006 Mar 2;49(5):671-82. PubMed.
  3. . Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. J Neurosci. 2006 Apr 5;26(14):3845-54. PubMed.
  4. . Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation. J Neurosci. 2007 Feb 21;27(8):1981-91. PubMed.

Further Reading

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